Reference : Beta3 integrins: major therapeutic targets of the near future.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Beta3 integrins: major therapeutic targets of the near future.
Schaffner-Reckinger, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg
Yes (verified by ORBilu)
[en] Biological Markers ; Cardiovascular Diseases/therapy ; Humans ; Integrin beta3/chemistry/physiology ; Platelet Aggregation ; Thrombasthenia/therapy
[en] Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets.

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