[en] Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets.
Disciplines :
Biochimie, biophysique & biologie moléculaire
Auteur, co-auteur :
SCHAFFNER-RECKINGER, Elisabeth ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Langue du document :
Anglais
Titre :
Beta3 integrins: major therapeutic targets of the near future.
Date de publication/diffusion :
2003
Titre du périodique :
Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg
ISSN :
0037-9247
Maison d'édition :
Société des Sciences Médicales du Grand-Duche de Luxembourg, Luxembourg
