Article (Scientific journals)
Beta3 integrins: major therapeutic targets of the near future.
Schaffner-Reckinger, Elisabeth
2003In Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg, (1), p. 23-34
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Keywords :
Biological Markers; Cardiovascular Diseases/therapy; Humans; Integrin beta3/chemistry/physiology; Platelet Aggregation; Thrombasthenia/therapy
Abstract :
[en] Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Schaffner-Reckinger, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Beta3 integrins: major therapeutic targets of the near future.
Publication date :
2003
Journal title :
Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg
ISSN :
0037-9247
Publisher :
Société des Sciences Médicales du Grand-Duche de Luxembourg, Luxembourg
Issue :
1
Pages :
23-34
Peer reviewed :
Peer Reviewed verified by ORBi
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