Article (Scientific journals)
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
Govindarajan, Nambirajan; Agis-Balboa, Roberto Carlos; Walter, Jonas et al.
2011In Journal of Alzheimer's Disease, 26 (1), p. 187-197
Peer reviewed
 

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Keywords :
Alzheimer's Disease; Sodium butyrate; memory function
Abstract :
[en] Dysregulation of histone acetylation has been implicated in the onset of age-associated memory impairment and the pathogenesis of neurodegenerative diseases. Elevation of histone acetylation via administration of histone deacetylase (HDAC) inhibitors is currently being pursued as a novel therapeutic avenue to treat memory impairment linked to Alzheimer's disease (AD). Here we show that severe amyloid pathology correlates with a pronounced dysregulation of histone acetylation in the forebrain of APPPS1-21 mice. Importantly, prolonged treatment with the pan-HDAC inhibitor sodium butyrate improved associative memory in APPPS1-21 mice even when administered at a very advanced stage of pathology. The recovery of memory function correlated with elevated hippocampal histone acetylation and increased expression of genes implicated in associative learning. These data advance our understanding of the potential applicability of HDAC inhibitors for the treatment of AD and suggest that HDAC inhibitors may have beneficial effects even when administered long after the onset of disease-associated symptoms.
Research center :
European Neuroscience Institute Goettingen, University Medicine Goettingen, Goettingen, Germany.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Govindarajan, Nambirajan
Agis-Balboa, Roberto Carlos
Walter, Jonas ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Sananbenesi, Farahnaz
Fischer, André
Language :
English
Title :
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
Publication date :
01 January 2011
Journal title :
Journal of Alzheimer's Disease
ISSN :
1387-2877
Publisher :
IOS Press
Volume :
26
Issue :
1
Pages :
187-197
Peer reviewed :
Peer reviewed
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since 11 October 2013

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