[en] The role of the microbiome in cancer metastasis has emerged as a critical area of research, with growing evidence suggesting that microbial composition and interactions within the tumour microenvironment may significantly influence metastatic progression. This review explores the role of the microbiome in cancer metastasis, as well as potential key bacteria and their mechanisms through which they could impact tumour dissemination, seeding and growth. Biological models used to study metastasis are discussed to provide context for the further investigation of these interactions. In order to answer unresolved questions regarding the microbiome's involvement in metastatic dissemination, recent advancements in spatial biology techniques are examined, including spatial genomics, transcriptomics, proteomics and metabolomics, which enable the spatial mapping of microbial interactions within the tumour microenvironment. Additionally, multimodal-omics imaging approaches are highlighted for their potential to integrate multiple molecular layers, offering comprehensive insights into the microbiome's role in cancer metastasis. The review also addresses the challenges and limitations of these techniques, underscoring the complexity of studying microbiome-tumour interactions and offering directions for future research to better explore and target the microbiological landscape in metastatic cancer.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
MEYERS, Marianne ✱; University of Luxembourg > Faculty of Science, Technology and Medicine > Department of Health, Medicine and Life Sciences > Team Elisabeth LETELLIER
STOFFELS, Charlotte ✱; University of Luxembourg ; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg
Frache, Gilles; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg
LETELLIER, Elisabeth ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Health, Medicine and Life Sciences (DHML)
Feucherolles, Maureen; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg
✱ These authors have contributed equally to this work.
External co-authors :
no
Language :
English
Title :
Microbiome in cancer metastasis: biological insights and emerging spatial omics methods.
Fonds De La Recherche Scientifique - FNRS Fondation du Pélican de Mie et Pierre Hippert-Faber Luxembourg Institute of Science and Technology
Funding text :
We are grateful to Lindsey Stokes (Luxembourg Institute of Science and Technology) for proof-reading and editing the manuscript. We also acknowledge the support of the Doctoral School in Science and Engineering (M.M.) and the Department of Life Sciences and Medicine at the University of Luxembourg.The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the FNRS-T\u00E9l\u00E9vie grant to M.M. (grant number 7.4565.21-40007364); Fondation du P\u00E9lican de Mie and Pierre Hippert-Faber under the aegis of the Fondation de Luxembourg (Pelican Grant\u2019 M.M); and internal fundings of the Luxembourg Institute of Science and Technology (LIST). Luxembourg National Research Fund (FNR) grants BRIDGES/2022/BM/17413841 (to EL), by the FNR and the Fondation Cancer Luxembourg grant CORE/C20/BM/14591557 (to EL). Acknowledgments
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