[en] Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive ageing. Here, we tested the utility of these scores as potential diagnostic and prognostic markers in Alzheimer's disease (AD) and risk states like mild cognitive impairment (MCI) or subjective cognitive decline (SCD). To this end, we analysed subsequent memory functional MRI data from individuals with SCD, MCI and AD dementia as well as healthy controls and first-degree relatives of AD dementia patients (AD-rel) who participated in the multi-centre DELCODE study (n = 468). Based on the individual participants' whole-brain functional MRI novelty and subsequent memory responses, we calculated the FADE and SAME scores and assessed their association with AD risk stage, neuropsychological test scores, CSF amyloid positivity and APOE genotype. Memory-based FADE and SAME scores showed a considerably larger deviation from a reference sample of young adults in the MCI and AD dementia groups compared to healthy controls, SCD and AD-rel. In addition, novelty-based scores significantly differed between the MCI and AD dementia groups. Across the entire sample, single-value scores correlated with neuropsychological test performance. The novelty-based SAME score further differed between Aβ-positive and Aβ-negative individuals in SCD and AD-rel, and between ApoE ɛ4 carriers and non-carriers in AD-rel. Hence, FADE and SAME scores are associated with both cognitive performance and individual risk factors for AD. Their potential utility as diagnostic and prognostic biomarkers warrants further exploration, particularly in individuals with SCD and healthy relatives of AD dementia patients.
Disciplines :
Neurology
Author, co-author :
Soch, Joram ; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany ; Bernstein Center for Computational Neuroscience (BCCN), 10117 Berlin, Germany ; Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS), 04103 Leipzig, Germany
Richter, Anni ; Department of Behavioral Neurology, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, Germany ; German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, 39120 Magdeburg, Germany ; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, 39120 Magdeburg, Germany
Kizilirmak, Jasmin M ; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany ; Research Area Educational Careers and Graduate Employment, German Center for Higher Education Research and Science Studies (DZHW), 30159 Hannover, Germany
Schütze, Hartmut; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany
Ziegler, Gabriel; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany
Altenstein, Slawek; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Brosseron, Frederic; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany
Dechent, Peter; MR-Research in Neurosciences, Department of Cognitive Neurology, Georg August University, 37075 Göttingen, Germany
Fliessbach, Klaus; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany
Freiesleben, Silka Dawn; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Glanz, Wenzel; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany
Gref, Daria; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Hetzer, Stefan; Berlin Center for Advanced Neuroimaging, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Incesoy, Enise I; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany ; Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, 39120 Magdeburg, Germany
Kilimann, Ingo; German Center for Neurodegenerative Diseases (DZNE), 18147 Rostock, Germany ; Department of Psychosomatic Medicine, Rostock University Medical Center, 18147 Rostock, Germany
Kimmich, Okka; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany
Kleineidam, Luca; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany
Kuhn, Elizabeth; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany
Laske, Christoph; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany ; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany
Lohse, Andrea; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Lüsebrink, Falk; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany
Munk, Matthias H; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany ; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany
Peters, Oliver; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Preis, Lukas; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Priller, Josef; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany ; School of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, 81675 Munich, Germany ; Centre for Clinical Brain Sciences, University of Edinburgh and UK DRI, Edinburgh EH16 4SB, UK
Ramirez, Alfredo ; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany ; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Köln, Germany ; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50924 Cologne, Germany ; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX 78229, USA
Roeske, Sandra; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany
Rostamzadeh, Ayda; Medical Faculty, Department of Psychiatry, University of Cologne, 50924 Cologne, Germany
Roy-Kluth, Nina; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany
Scheffler, Klaus; Department for Biomedical Magnetic Resonance, University of Tübingen, 72076 Tübingen, Germany
Schmid, Matthias; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Institute for Medical Biometry, University Hospital Bonn, 53127 Bonn, Germany
Schneider, Anja; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany
Spottke, Annika; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurology, University of Bonn, 53127 Bonn, Germany
Spruth, Eike Jakob; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
Teipel, Stefan ; German Center for Neurodegenerative Diseases (DZNE), 18147 Rostock, Germany ; Department of Psychosomatic Medicine, Rostock University Medical Center, 18147 Rostock, Germany
Wiltfang, Jens; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany ; Department of Psychiatry and Psychotherapy, University Medical Center, 37075 Göttingen, Germany ; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
Jessen, Frank; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Köln, Germany ; Medical Faculty, Department of Psychiatry, University of Cologne, 50924 Cologne, Germany
Wagner, Michael; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany
Düzel, Emrah ; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany ; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany
Schott, Björn H ; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany ; Department of Behavioral Neurology, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, Germany ; Department of Psychiatry and Psychotherapy, University Medical Center, 37075 Göttingen, Germany ; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany
German Center for Neurodegenerative Diseases Deutsche Forschungsgemeinschaft
Funding text :
This work was supported by the German Center for Neurodegenerative Diseases (Deutsches Zentrum f\u00FCr Neurodegenerative Erkrankungen, DZNE; reference number BN012). The authors further received support from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG; CRC 1436, projects A05, C01, and Z03) and by grants from the European Union and the State of Saxony-Anhalt to E.D. and B.H.S. (Research Alliance \u2018Autonomy in Old Age\u2019).
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