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From Data to Value: Gaps in Federated Learning Evaluation for Clinical Deployment in Medical Imaging
GARCIA SANTA CRUZ, Beatriz; Malak, Jaleh Shoshtarian; CWIEK-KUPCZYNSKA, Hanna et al.
2025In Lecture Notes in Computer Science
Peer reviewed
 

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Keywords :
Federated Learning; Value-Based Healthcare; Global regulatory frameworks; Quality Management System; Trustworthy AI
Abstract :
[en] Federated Learning (FL) offers a promising solution to the dual challenges of data privacy and multi-institutional collaboration in medical imaging. However, despite strong benchmark performance, FL models rarely reach routine clinical deployment. We hypothesize that this “last-mile” gapstemsfromamisalignmentbetweencurrentFLevaluation- focused on technical metrics-and the priorities of value-based healthcare (VBHC). We conduct a structured gap analysis comparing current FL practices with VBHC principles and emerging regulatory frameworks. Seven critical deployment axes are identified; six show high-severity gaps, and one a medium - severity gap.Supporting literature is limited:only one axis is backed by strong evidence, three by moderate, one by weak, and two by very weak reviews. Based on these findings and insights from real- world pilots, we propose a practical roadmap to align FL development with clinical and regulatory expectations. By identifying key evidence gaps and outlining actionable next steps, this work aims to inform trans- lational strategies and support the deployment challenges addressed by the BRIDGE Workshop.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
Disciplines :
Computer science
Author, co-author :
GARCIA SANTA CRUZ, Beatriz  ;  University of Luxembourg
Malak, Jaleh Shoshtarian 
CWIEK-KUPCZYNSKA, Hanna  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Clinical and Translational Informatics
SATAGOPAM, Venkata  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Clinical and Translational Informatics
External co-authors :
no
Language :
English
Title :
From Data to Value: Gaps in Federated Learning Evaluation for Clinical Deployment in Medical Imaging
Original title :
[en] From Data to Value: Gaps in Federated Learning Evaluation for Clinical Deployment in Medical Imaging
Publication date :
25 September 2025
Main work title :
Lecture Notes in Computer Science
Publisher :
Springer Nature Switzerland
ISBN/EAN :
978-3-03-205663-4
978-3-03-205665-8
Pages :
46-55
Peer reviewed :
Peer reviewed
Focus Area :
Computational Sciences
Development Goals :
3. Good health and well-being
European Projects :
HE - 101112135 - IDERHA - Integration of heterogeneous Data and Evidence towards Regulatory and HTA Acceptance
H2020 - 101034344 - EPND - European platform for neurodegenerative disorders
FnR Project :
23/16695277
Name of the research project :
Clinnova project
Funders :
FNR - Fonds National de la Recherche
European Union
Funding number :
23/16695277
Available on ORBilu :
since 03 October 2025

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