cross‐α structure; functional amyloids; green energy harvesting; helicity inversion; nanotechnology; peptide self‐assembly; piezoelectric biomaterials; cross-alpha structure
Résumé :
[en] Although initially identified as pathological aggregates, amyloid fibrillar assemblies formed by various proteins and peptides are now known to have crucial physiological roles, carrying out numerous biological functions in almost all organisms. Due to unique features, the common etiology of amyloids' cross-β structure is long posited as a template for designing artificial self-assembling systems. However, the recent discovery of cross-α amyloids indicates additional structural paradigms for self-assembly into ordered nanostructures, turning significant attention toward designing artificial nanostructures based on cross-α assembly. Herein, a minimalistic designer peptide which forms a hydrogen-bonded amyloid-like structure while remaining in the α region of conformation is engineered, to investigate the effect of aromatic, hydrophobic, and steric considerations on amyloidal assemblies. These results demonstrate a significant modulation of helicity and self-assembly, leading to the structure-dependent piezoelectric function of the amyloid-like cross-α fibrils. This study indicates a potential avenue for molecular engineering of functional peptide materials.
Centre de recherche :
ULHPC - University of Luxembourg: High Performance Computing
Disciplines :
Physique, chimie, mathématiques & sciences de la terre: Multidisciplinaire, généralités & autres
Auteur, co-auteur :
Dey, Sukantha; Department of Chemistry, Ashoka University, Sonipat, Haryana, 131029, India
Field, Emily H; Department of Biochemistry & Chemistry, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, 3086, Australia
Wang, Yuehui; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China
HAN, Kyunghoon ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)
Kumar, Rohit; Department of Chemistry, Ashoka University, Sonipat, Haryana, 131029, India
Shimon, Linda J W; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel
Liu, Shuaijie; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China
Guerin, Sarah; Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, V94 T9PX, Ireland ; SSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Limerick, V94 T9PX, Ireland
BERRYMAN, Josh ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)
Ji, Wei; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China
Reynolds, Nicholas P; Department of Biochemistry & Chemistry, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, 3086, Australia ; The Biomedical and Environmental Sensor Technology (BEST) Research Centre, Biosensors Program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, 3086, Australia
Bera, Santu ; Department of Chemistry, Ashoka University, Sonipat, Haryana, 131029, India
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Fluorination Induced Inversion of Helicity and Self-Assembly Into Cross-α Like Piezoelectric Amyloids by Minimalistic Designer Peptide.
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