[en] Neuroinflammation, characterized by a complex interplay among innate and adaptive immune responses within the central nervous system (CNS), is crucial in responding to infections, injuries, and disease pathologies. However, the dysregulation of the neuroinflammatory response could significantly affect neurons in terms of function and structure, leading to profound health implications. Although tremendous progress has been made in understanding the relationship between neuroinflammatory processes and alterations in neuronal integrity, the specific implications concerning both structure and function have not been extensively covered, with the exception of perspectives on glial activation and neurodegeneration. Thus, this review aims to provide a comprehensive overview of the multifaceted interactions among neurons and key inflammatory players, exploring mechanisms through which inflammation influences neuronal functionality and structural integrity in the CNS. Further, it will discuss how these inflammatory mechanisms lead to impairment in neuronal functions and architecture and highlight the consequences caused by dysregulated neuronal functions, such as cognitive dysfunction and mood disorders. By integrating insights from recent research findings, this review will enhance our understanding of the neuroinflammatory landscape and set the stage for future interventions that could transform current approaches to preserve neuronal integrity and function in CNS-related inflammatory conditions.
Précision sur le type de document :
Compte rendu
Disciplines :
Sciences du vivant: Multidisciplinaire, généralités & autres
HENEKA, Michael ; University of Luxembourg ; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, North Worcester, Massachusetts, USA
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
The impact of neuroinflammation on neuronal integrity.
Graphical illustrations were created using BioRender ( https://biorender.com/ ). Bora TASTAN is a recipient of the EMBO Postdoctoral Fellowship and has been supported by EMBO (ALTF 962\u20102022).
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