Fibrinogen; Humans; Fibrinogen/analysis; Fibrinogen/chemistry; Particle Size; Volatilization; Surface Properties; Erythrocytes/chemistry; Erythrocytes/cytology; Blood samples; Coffee rings; Diagnostics tools; Intensive research; Low concentrations; Low-costs; Red blood cell; Sample solution; Sessile droplet; Study samples; Erythrocytes; Electronic, Optical and Magnetic Materials; Biomaterials; Surfaces, Coatings and Films; Colloid and Surface Chemistry
Abstract :
[en] Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is considered a potential low-cost diagnostic tool. So far, samples with a volume fraction down to a few percent of red blood cells have been studied, and these were reportedly dominated by a "coffee-ring" deposit. In this study, samples with lower volume fractions were used to investigate the growth of the evaporative deposit from sessile droplets in more detail. We observed that blood samples and salt solutions with less than 1% volume fraction of red blood cells are dominated by a central deposit. We characterized the growth process of this central deposit by evaporating elongated drops and determined that it is consistent with the Kardar-Parisi-Zhang process in the presence of quenched disorder. Our results showed a sensitivity of the deposit size to fibrinogen concentration and the shape of red blood cells, suggesting that this parameter could be developed into a new and cost-effective clinical marker for inflammation and red blood cell deformation.
Disciplines :
Physics
Author, co-author :
Sardari, Vahideh ; Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran, Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Mohammadian, Mahsa ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Asfia, Shima ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Maurer, Felix; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Örüm, Diana; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Seemann, Ralf ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
John, Thomas ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany
Kaestner, Lars ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany, Department of Theoretical Medicine and Biosciences, Saarland University, Homburg, D-66421, Germany
Maleki, Maniya; Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran
Darras, Alexis ; Department of Experimental Physics & Center for Biophysics, Saarland University, Saarbruecken, D-66123, Germany. Electronic address: alexis.darras@uni-saarland.de
External co-authors :
yes
Language :
English
Title :
Deposit of Red Blood Cells at low concentrations in evaporating droplets is dominated by a central edge growth.
Ministry of Science Research and Technology of the Islamic Republic of Iran Saarland University
Funding text :
V.S. ackowledges funding from Ministry of Science, Research, and Technology of Iran for her research stay in Germany. A.D. acknowledges funding by the Young Investigator Grant of the Saarland University.
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