Cue reactivity; Dorsolateral prefrontal cortex; Reward availability; Ventral striatum; fMRI; rTMS; Humans; Prefrontal Cortex/physiology; Brain; Transcranial Magnetic Stimulation/methods; Reward; Dorsolateral Prefrontal Cortex; Cues; Prefrontal Cortex; Transcranial Magnetic Stimulation; Neuropsychology and Physiological Psychology; Experimental and Cognitive Psychology; Cognitive Neuroscience
Abstract :
[en] Brain imaging studies have shown that stimulation of the left dorsolateral prefrontal cortex (dlPFC), which plays a pivotal role in high-order cognitive control processes, modulates brain reactivity to reward-related cues. Nevertheless, the impact of contextual factors such as reward availability (the reward that is depicted in the cue exposure task) on such modulation effect remains unclear. Here we tested whether a single session of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dlPFC differently impacts brain reactivity to cues signalling either availability or unavailability of a sports betting opportunity. Employing a within-subject design (verum versus sham HF-rTMS) among thirty-two frequent sports bettors, we first observed that, as compared to the sham condition, verum HF-rTMS modulated brain reactivity to game cues prior to being made (un)available for betting, through simultaneous increases (posterior insula and caudate nucleus) and decreases (occipital pole) in brain activation. Second, verum HF-rTMS led to increased ventral striatal activity towards cues available for betting but did not modulate brain response to cues unavailable for betting. Taken together, these findings demonstrate that transient stimulation of the left dlPFC led to a general modulation in brain activity in responses to cues, and that this effect is only partly dependent on cues signalling for reward (un)availability.
Disciplines :
Neurosciences & behavior
Author, co-author :
BREVERS, Damien ✱; University of Luxembourg > Faculty of Humanities, Education and Social Sciences > Department of Behavioural and Cognitive Sciences > Team Claus VÖGELE
Baeken, Chris; Department of Psychiatry University Hospital (UZBrussel), Brussels, Belgium, Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium, Department of Head and Skin, Ghent University Hospital, Ghent University, Ghent, Belgium, Eindhoven University of Technology, Department of Electrical Engineering, Eindhoven, the Netherlands
De Smet, Stefanie; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium
Catoira, Beatriz; Department of Psychiatry University Hospital (UZBrussel), Brussels, Belgium
De Witte, Sara; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium
He, Qinghua; Faculty of Psychology, Southwest University, 2 Tiansheng Rd, Chongqing, China
Maurage, Pierre; Louvain for Experimental Psychopathology Research Group (LEP), Psychological Sciences Research Institute (IPSY), UCLouvain, Louvain-la-Neuve, Belgium
SCHULZE-STEINEN, Laimi Marja Elina ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences > Department of Behavioural and Cognitive Sciences > Team Claus VÖGELE
Sescousse, Guillaume; Lyon Neuroscience Research Center - INSERM U1028 - CNRS UMR5292, PSYR2 Team, University of Lyon, Lyon, France
Verde, Claudia Vila; Institute for Health and Behaviour, Department of Behavioural and Cognitive Sciences, University of Luxembourg, Esch-sur-Alzette, Luxembourg
VÖGELE, Claus ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) > Health and Behaviour
Billieux, Joël ✱; Institute of Psychology, University of Lausanne, Lausanne, Switzerland, Centre for Excessive Gambling, Addiction Medicine, Lausanne University Hospitals (CHUV), Lausanne, Switzerland
✱ These authors have contributed equally to this work.
External co-authors :
yes
Language :
English
Title :
Stimulation of the dorsolateral prefrontal cortex modulates brain cue reactivity to reward (un)availability.
Publication date :
July 2023
Journal title :
Cortex: A Journal Devoted to the Study of the Nervous System and Behavior
R-AGR-3548 - C18/BM/12552025 BETHAB - part UL - VÖGELE Claus
Funders :
FNR - Fonds National de la Recherche
Funding text :
The work of D.B. is supported by the Luxembourg National Research Fund (FNR) ; CORE – Junior Track [BETHAB; C18/BM/12552025 ]. P.M. (Senior Research Associate) is funded by the Belgian Fund for Scientific Research (F.R.S.-FNRS, Belgium). These funds did not exert any editorial direction or censorship on any part of this article. All authors declare no conflicts of interest relevant to this manuscript. The authors would like to thank Anita Cebolla and Mathieu Petieau for their help in running the brain stimulation sessions.
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