[en] [en] OBJECTIVE: To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with CSF biomarkers of Alzheimer disease (AD).
METHOD: We analyzed data from n = 449 cognitively normal participants (n = 209 healthy controls, n = 240 patients with SCD) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, 5 cognitive domain factor structure comprising learning and memory, executive functions, language abilities, working memory, and visuospatial functions. We compared groups in terms of global and domain-specific performance and correlated performance with different CSF markers of AD pathology.
RESULTS: We observed worse performance (Cohen d = ≈0.25-0.5, adjusted for age, sex differences with analysis of covariance) in global performance, memory, executive functions, and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r = ≈0.3) associated with lower CSF β-amyloid42/40 and CSF β-amyloid42/phosphorylated tau181 in the whole sample and specifically in the SCD subgroup.
CONCLUSIONS: Within the spectrum of clinically unimpaired (i.e., before mild cognitive impairment) cognitive performance, SCD is associated with minor deficits in memory, executive function, and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.
Disciplines :
Neurology
Author, co-author :
Wolfsgruber, Steffen; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany. Steffen.Wolfsgruber@dzne.de
Kleineidam, Luca; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Guski, Jannis; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Polcher, Alexandra; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Frommann, Ingo; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Roeske, Sandra; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Spruth, Eike Jakob; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Franke, Christiana; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Priller, Josef; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Kilimann, Ingo; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Teipel, Stefan; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Buerger, Katharina; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Janowitz, Daniel; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Laske, Christoph; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Buchmann, Martina; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Peters, Oliver; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Menne, Felix; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Fuentes Casan, Manuel; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Wiltfang, Jens; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Bartels, Claudia; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Düzel, Emrah; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Metzger, Coraline; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Glanz, Wenzel; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Thelen, Manuela; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Spottke, Annika; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Ramirez, Alfredo ; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Kofler, Barbara; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Fließbach, Klaus; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Schneider, Anja; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
HENEKA, Michael ; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Brosseron, Frederic; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Meiberth, Dix; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Jessen, Frank; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Wagner, Michael ; From the German Center for Neurodegenerative Diseases (S.W., L.K., J.G., A.P., I.F., S.R., M.T., A. Spottke, A.R., B.K., K.F., A. Schneider, M.H., F.B., D.M., F.J., M.W.), Department of Neurodegenerative Diseases and Geriatric Psychiatry (S.W., L.K., J.G., A.P., I.F., A.R., B.K., K.F., A. Schneider, M.T.H., F.B., M.W.), University of Bonn, German Center for Neurodegenerative Diseases (E.J.S., J.P., O.P., F.M., M.F.C.), Department of Psychiatry and Psychotherapy (E.J.S., C.F., J.P.), Charité-Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases (I.K., S.T.), Department of Psychosomatic Medicine (I.K., S.T.), Rostock University Medical Center, German Center for Neurodegenerative Diseases (K.B.), Institute for Stroke and Dementia Research (K.B., D.J.), University Hospital, LMU Munich, German Center for Neurodegenerative Diseases (C.L., M.B.), Section for Dementia Research (C.L., M.B.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Charité-Universitätsmedizin Berlin (O.P., F.M., M.F.C.), corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, (O.P., F.M., M.F.C.), Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, German Center for Neurodegenerative Diseases (J.W., C.B.), Department of Psychiatry and Psychotherapy (J.W., C.B.), University Medical Center Goettingen, University of Goettingen, German Center for Neurodegenerative Diseases (E.D., C.M.), Institute of Cognitive Neurology and Dementia Research (E.D., C.M., W.G.) and Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg, Department of Neurology (A. Spottke), University Hospital Bonn, and Division of Neurogenetics and Molecular Psychiatry (A.R.) and Department of Psychiatry (M.T., D.M., F.J.), Medical Faculty University of Cologne, Germany
Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement 2014; 10: 844-852.
Molinuevo JL, Rabin LA, Amariglio R, et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement 2017; 13: 296-311.
Mitchell AJ, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B,. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatrica Scand 2014; 130: 439-451.
Slot RER, Sikkes SAM, Berkhof J, et al. Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers Dement 2019; 15: 465-476.
Rabin LA, Smart CM, Amariglio RE,. Subjective cognitive decline in preclinical Alzheimer's disease. Annu Rev Clin Psychol 2017; 13: 369-396.
Jessen F, Spottke A, Boecker H, et al. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimers Res Ther 2018; 10: 15.
Dowling NM, Hermann B, La Rue A, Sager MA,. Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease. Neuropsychology 2010; 24: 742-756.
Park LQ, Gross AL, McLaren DG, et al. Confirmatory factor analysis of the ADNI neuropsychological battery. Brain Imaging Behav 2012; 6: 528-539.
Folstein MF, Folstein SE, McHugh PR,. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
Mohs RC, Knopman D, Petersen RC, et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope: the Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997; 11 (suppl 2): S13-S21.
Grober E, Ocepek-Welikson K, Teresi JA,. The Free and Cued Selective Reminding Test: evidence of psychometric adequacy. Psychol Sci Q 2009; 51: 266-282.
Petermann F, Lepach AC,. Wechsler Memory Scale-Fourth Edition (WMS-IV): Manual zur Durchführung und Auswertung: Deutsche Übersetzung und Adaptation der WMS-IV von David Wechsler. Frankfurt: Pearson Assessment; 2012.
Lezak MD,. Neuropsychological Assessment. Oxford: Oxford University Press; 2004.
Thalmann B, Monsch AU, Schneitter M, et al. The CERAD Neuropsychological Assessment Battery (CERAD-NAB): a minimal data set as a common tool for German-speaking Europe. Neurobiol Aging 2000; 21: 30.
Smith A,. Symbol Digit Modalities Test (SDMT) Manual (Revised). Los Angeles: Western Psychological Services; 1982.
Reitan RM,. Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot skills 1958; 8: 271-276.
Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K,. Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease. Brain Cogn 1992; 18: 70-87.
Polcher A, Frommann I, Koppara A, Wolfsgruber S, Jessen F, Wagner M,. Face-name associative recognition deficits in subjective cognitive decline and mild cognitive impairment. J Alzheimers Dis 2017; 56: 1185-1196.
Van Dam, Nicholas T, Sano M, et al. Functional neural correlates of attentional deficits in amnestic mild cognitive impairment. PLoS One 2013; 8: e54035.
Miebach L, Wolfsgruber S, Polcher A, et al. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study. Alzheimers Res Ther 2019; 11: 66.
Lewczuk P, Kornhuber J, Toledo JB, et al. Validation of the Erlangen score algorithm for the prediction of the development of dementia due to Alzheimer's disease in pre-dementia subjects. J Alzheimers Dis 2016; 49: 887.
Jack CR, Bennett DA, Blennow K, et al. NIA-AA Research Framework: toward a biological definition of Alzheimer's disease. Alzheimers Dement 2018; 14: 535-562.
Bjerke M, Engelborghs S,. Cerebrospinal fluid biomarkers for early and differential Alzheimer's disease diagnosis. J Alzheimers Dis 2018; 62: 1199-1209.
Snitz BE, Lopez OL, McDade E, et al. Amyloid-β imaging in older adults presenting to a memory clinic with subjective cognitive decline: a pilot study. J Alzheimers Dis 2015; 48 (suppl 1): S151-S159.
Perrotin A, La Joie R, de La Sayette V, et al. Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: differential affective and imaging correlates. Alzheimers Dement 2017; 13: 550-560.
Mattsson N, Insel PS, Palmqvist S, et al. Increased amyloidogenic APP processing in APOE ϵ4-negative individuals with cerebral β-amyloidosis. Nat Commun 2016; 7: 10918.
Curran PJ, Hussong AM,. Integrative data analysis: the simultaneous analysis of multiple data sets. Psychol Methods 2009; 14: 81-100.
Delis DC, Jacobson M, Bondi MW, Hamilton JM, Salmon DP,. The myth of testing construct validity using factor analysis or correlations with normal or mixed clinical populations: lessons from memory assessment. J Int Neuropsychological Soc 2003; 9: 936-946.
Crane PK, Trittschuh E, Mukherjee S, et al. Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. Alzheimers Dement 2017; 13: 1307-1316.
Bäckman L, Jones S, Berger A, Laukka EJ, Small BJ,. Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. Neuropsychology 2005; 19: 520.
Baker JE, Lim YY, Pietrzak RH, et al. Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: a meta-analysis. Alzheimers Dement Diagn Assess Dis Monit 2017; 6: 108-121.
Schneider AL, Senjem ML, Wu A, et al. Neural correlates of domain-specific cognitive decline. Neurology 2019; 92: e1051-e1063.
Timmers T, Ossenkoppele R, Verfaillie SCJ, et al. Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project. Neurobiol Aging 2019; 79: 50-58.
van Harten AC, Smits LL, Teunissen CE, et al. Preclinical AD predicts decline in memory and executive functions in subjective complaints. Neurology 2013; 81: 1409.
Verfaillie SCJ, Witteman J, Slot RER, et al. High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline. Neuropsychologia 2019; 131: 184-192.
Verfaillie, Sander CJ, Pichet Binette A, et al. Subjective cognitive decline is associated with altered default mode network connectivity in individuals with a family history of Alzheimer's disease. Biol Psychiatry Cogn Neurosci Neuroimaging 2018; 3: 463-472.
Early Alzheimer's Disease: Developing Drugs for Treatment: Guidance for Industry. Washington, DC: US Department of Health and Human Services Food and Drug Administration; 2018.
Vogel JW, Doležalová MV, La Joie R, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly. Neurology 2017; 89: 2002-2009.
Buckley RF, Maruff P, Ames D, et al. Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimers Demen 2016; 12: 796-804.
Rueda AD, Lau KM, Saito N, et al. Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. Alzheimers Dement 2015; 11: 1080-1089.
Wolfsgruber S, Molinuevo JL, Wagner M, et al. Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimers Res Ther 2019; 11: 8.
