[en] Diseases of the central nervous system present a challenge for the development of new therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have proven to be valuable targets for development of new drugs owing to their ability to directly regulate gene expression. The nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), has been investigated for its action in ameliorating the development and progression of a number of CNS diseases. PPARgamma agonists exhibit potent anti-inflammatory effects and appear to have direct neuroprotective actions. PPARgamma agonists have been shown to be efficacious in animal models of Alzheimer's disease, stroke, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis. The availability of FDA-approved agonists of this receptor will facilitate the rapid translation of these findings into clinical trials for a number of CNS diseases.
Disciplines :
Neurology
Author, co-author :
Sundararajan, Sophia; Department of Neurology, Case Western Reserve University, Cleveland, OH 44106-4928, United States
Jiang, Qingguang; Department of Neurology, Case Western Reserve University, Cleveland, OH 44106, United States ; Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, United States
HENEKA, Michael ; Department of Neurology, University of Münster, Münster, D14849, Germany
Landreth, Gary; Department of Neurology, Case Western Reserve University, Cleveland, OH 44106, United States ; Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, United States
External co-authors :
yes
Language :
English
Title :
PPARgamma as a therapeutic target in central nervous system diseases.
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