[en] Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.
Disciplines :
Neurology
Author, co-author :
Ersoezlue, Ersin ✱; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Rauchmann, Boris-Stephan ✱; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK
Schneider-Axmann, Thomas ; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Wagner, Michael ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Ballarini, Tommaso; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Tato, Maia ; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Utecht, Julia; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Kurz, Carolin; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Papazov, Boris; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Guersel, Selim; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Burow, Lena; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Koller, Gabriele; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Stöcklein, Sophia; Department of Radiology, University Hospital, LMU Munich, Munich, Germany
Keeser, Daniel ; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Bartels, Claudia; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany
Brosseron, Frederic ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Buerger, Katharina; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Cetindag, Arda C; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany
Dechent, Peter; MR-Research in Neurology and Psychiatry, Georg-August-University Göttingen, Germany
Dobisch, Laura; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Ewers, Michael; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Fliessbach, Klaus; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Frommann, Ingo ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Haynes, John D; Bernstein Center for Computational Neuroscience, Charité - Universitätsmedizin, Berlin, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Janowitz, Daniel; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Kilimann, Ingo; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany, Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
Kleinedam, Luca; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Laske, Christoph; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Maier, Franziska ; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany
Metzger, Coraline D; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany, Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany
Munk, Matthias H; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Peters, Oliver; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Preis, Lukas ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Priller, Josef; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany, Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany
Ramirez, Alfredo ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany, Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany
Roeske, Sandra ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Roy, Nina; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Scheffler, Klaus; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany
Schneider, Anja; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Spottke, Annika; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department of Neurology, University of Bonn, Bonn, Germany
Spruth, Eike J ; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany
Teipel, Stefan; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany, Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
Wiltfang, Jens; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany, Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
Wolfsgruber, Steffen; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany
Yakupov, Renat ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Duezel, Emrah; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany
Jessen, Frank; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany
Perneczky, Robert; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany, Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK, Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK. Electronic address: robert.perneczky@med.lmu.de
Deutsches Zentrum für Neurodegenerative Erkrankungen
Funding text :
The DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study was funded by the German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE), reference number BN012.
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