Alzheimer’s disease; Bayesian inference; Brain ageing; Brain morphology; Classification; Cognitive decline; Gaussian processes; Predictive modeling; Alzheimers disease; Brain aging; Brain morphologies; Clinical outcome; Covariates; Memory performance; Predictive models; Radiological and Ultrasound Technology; Radiology, Nuclear Medicine and Imaging; Computer Vision and Pattern Recognition; Health Informatics; Computer Graphics and Computer-Aided Design
Abstract :
[en] Neuroimaging markers based on Magnetic Resonance Imaging (MRI) combined with various other measures (such as genetic covariates, biomarkers, vascular risk factors, neuropsychological tests etc.) might provide useful predictions of clinical outcomes during the progression towards Alzheimer's disease (AD). The use of multiple features in predictive frameworks for clinical outcomes has become increasingly prevalent in AD research. However, many studies do not focus on systematically and accurately evaluating combinations of multiple input features. Hence, the aim of the present work is to explore and assess optimal combinations of various features for MR-based prediction of (1) cognitive status and (2) biomarker positivity with a multi-kernel learning Gaussian process framework. The explored features and parameters included (A) combinations of brain tissues, modulation, smoothing, and image resolution; (B) incorporating demographics & clinical covariates; (C) the impact of the size of the training data set; (D) the influence of dimensionality reduction and the choice of kernel types. The approach was tested in a large German cohort including 959 subjects from the multicentric longitudinal study of cognitive impairment and dementia (DELCODE). Our evaluation suggests the best prediction of memory performance was obtained for a combination of neuroimaging markers, demographics, genetic information (ApoE4) and CSF biomarkers explaining 57% of outcome variance in out-of-sample predictions. The highest performance for Aβ42/40 status classification was achieved for a combination of demographics, ApoE4, and a memory score while usage of structural MRI further improved the classification of individual patient's pTau status.
Disciplines :
Neurology
Author, co-author :
Nemali, A ; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Germany, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. Electronic address: aditya.nemali@dzne.de
Vockert, N ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Berron, D ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Maas, A ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Bernal, J ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Yakupov, R ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Peters, O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Hindenburgdamm 30, 12203, Berlin, Germany
Gref, D; Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Hindenburgdamm 30, 12203, Berlin, Germany
Cosma, N ; Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Hindenburgdamm 30, 12203, Berlin, Germany
Preis, L ; Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Hindenburgdamm 30, 12203, Berlin, Germany
Priller, J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117 Berlin, Germany, School of Medicine, Technical University of Munich, Department of Psychiatry and Psychotherapy, Munich, Germany, University of Edinburgh and UK DRI, Edinburgh, UK
Spruth, E; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117 Berlin, Germany
Altenstein, S; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117 Berlin, Germany
Lohse, A; Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117 Berlin, Germany
Fliessbach, K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, University of Bonn Medical Center, Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Venusberg-Campus 1, 53127 Bonn, Germany
Kimmich, O; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Vogt, I; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Wiltfang, J ; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany, Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany, Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
Hansen, N; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany
Bartels, C ; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany
Schott, B H; Leibniz Institute for Neurobiology, Magdeburg, Germany, German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany, Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany
Maier, F ; Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924 Cologne, Germany
Meiberth, D; Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924 Cologne, Germany
Glanz, W ; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Germany
Incesoy, E ; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Germany, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Butryn, M; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Buerger, K; German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377 Munich, Germany, Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377 Munich, Germany
Janowitz, D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377 Munich, Germany
Pernecky, R; German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377 Munich, Germany, Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany, Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK
Rauchmann, B ; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Burow, L; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Teipel, S ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany, Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147 Rostock, Germany
Kilimann, I ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany, Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147 Rostock, Germany
Göerß, D ; Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147 Rostock, Germany
Dyrba, M ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany
Laske, C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Munk, M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
Sanzenbacher, C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
Müller, S; Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
Spottke, A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Roy, N; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, Department of Psychiatry and Psychotherapy, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Brosseron, F ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Roeske, S ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Dobisch, L; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Ramirez, A ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany, Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA
Ewers, M; German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377 Munich, Germany, Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377 Munich, Germany
Dechent, P; MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University Goettingen, Germany
Scheffler, K ; Department for Biomedical Magnetic Resonance, University of Tübingen, 72076 Tübingen, Germany
Kleineidam, L; University of Bonn Medical Center, Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Venusberg-Campus 1, 53127 Bonn, Germany
Wolfsgruber, S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, University of Bonn Medical Center, Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Venusberg-Campus 1, 53127 Bonn, Germany
Wagner, M ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, University of Bonn Medical Center, Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Venusberg-Campus 1, 53127 Bonn, Germany
Jessen, F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 53127 Bonn, Germany, Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924 Cologne, Germany, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany
Duzel, E ✱; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Germany, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Ziegler, G ✱; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Germany, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
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