[en] Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.
Disciplines :
Neurology
Author, co-author :
Hansen, Niels; Department of Psychiatry and Psychotherapy, Göttingen, Germany ; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany
Singh, Aditya; Department of Psychiatry and Psychotherapy, Göttingen, Germany ; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany
Bartels, Claudia; Department of Psychiatry and Psychotherapy, Göttingen, Germany
Brosseron, Frederic; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Buerger, Katharina; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany ; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Cetindag, Arda C; Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Dobisch, Laura; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Dechent, Peter; MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany
Ertl-Wagner, Birgit B; Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany
Fliessbach, Klaus; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Haynes, John D; Bernstein Center for Computational Neuroscience, Charité-Universitätsmedizin, Berlin, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Janowitz, Daniel; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Kilimann, Ingo; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany ; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
Laske, Christoph; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany ; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Tübingen, Germany ; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Metzger, Coraline D; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany ; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany
Munk, Matthias H; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany ; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Tübingen, Germany ; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
Peters, Oliver; Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Priller, Josef; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany ; Department of Psychiatry and Psychotherapy, Berlin, Germany
Roy, Nina; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Scheffler, Klaus; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany
Schneider, Anja; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Spottke, Annika; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany ; Department of Neurology, University of Bonn, Bonn, Germany
Spruth, Eike J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany ; Department of Psychiatry and Psychotherapy, Berlin, Germany
Teipel, Stefan; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany ; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany
Tscheuschler, Maike; Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany
Vukovich, Ruth; Department of Psychiatry and Psychotherapy, Göttingen, Germany
Wiltfang, Jens; Department of Psychiatry and Psychotherapy, Göttingen, Germany ; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany ; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal
Duezel, Emrah; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany
Jessen, Frank; Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany ; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany
Goya-Maldonado, Roberto; Department of Psychiatry and Psychotherapy, Göttingen, Germany ; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany
This work was promoted by the University Medical Center Göttingen (UMG) and the German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF: 01 ZX 1507, PreNeSt—e:Med). We thank Christine Werner, Sören Noack, Maria Keil, Tracy Erwin-Grabner, Vladimir Belov, and Esther Semmelhack for their contribution to data collection and organization.ASc got funding from Novartis, Diagnostik Netz BB (travel and speaker honoraria) and gained research support from German Federal Ministry of Research (BMBF), Actelion and Helmholtz Foundation Michael J Fox Foundation. CB received honoraria as a diagnostic consultant for Boehringer Ingelheim. DJ has obtained funding for travel from Pfizer GmbH. IK has obtained funding from the German ministry of economic cooperation and development. JP got research support for travel or speaker honoraria from Axon, CHDI, and UK DRI. He received research funding from DFG, BMBF, and UK DRI. JW has obtained research support from the Eli Lilly Advisory Board, Pfizer, MSD, and med Update GmbH (travel and speaker honoraria). He obtained research support from the BMBF. MH received funding for research support from the DFG. OP has obtained research support for travel or speaker honoraria from Schwabe. He has received funding from Eli Lilly, Lundbeck, Genentech, Biogen, Roche, Pharmatrophix, Novartis, Janssen, and Probiodrug. ST has gained support (travel or speaker honoraria) from MSD Sharp and Dohme GmbH Quality circle for physicians in Kühlungsborn and research support from ROCHE, Roche Pharma AG, Lilly Deutschland GmbH, BMBF, and Ministry of Economics of the State Mecklenburg Western Pomerania.
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