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Article (Scientific journals)

Do infections have a role in the pathogenesis of Alzheimer disease?

Itzhaki, Ruth F; Golde, Todd E; HENEKA, Michael et al.

2020 • In Nature Reviews. Neurology, 16 (4), p. 193 - 197

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https://hdl.handle.net/10993/61118

DOI
10.1038/s41582-020-0323-9

PubMed
32152461

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Keywords :

Apolipoprotein E4; Alzheimer Disease/etiology; Alzheimer Disease/genetics; Alzheimer Disease/microbiology; Apolipoprotein E4/genetics; Borrelia burgdorferi; Brain/microbiology; Chlamydophila pneumoniae; Herpesvirus 1, Human; Herpesvirus 6, Human; Herpesvirus 7, Human; Humans; Infections/complications; Infections/microbiology; Porphyromonas gingivalis; Alzheimer Disease; Brain; Infections; Neurology (clinical); Cellular and Molecular Neuroscience

Abstract :

[en] The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 years ago. However, this theory failed to gain substantial traction and was largely disregarded by the AD research community for many years. Several recent discoveries have reignited interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's Association International Conference (AAIC) in July 2019. In this Viewpoint article, experts who participated in the AAIC debate weigh up the evidence for and against the infectious theory of AD and suggest avenues for future research and drug development.

Disciplines :

Neurology

Author, co-author :

Itzhaki, Ruth F ; School of Biological Sciences, University of Manchester, Manchester, UK. ruth.itzhaki@manchester.ac.uk ; Institute of Population Ageing, University of Oxford, Oxford, UK. ruth.itzhaki@manchester.ac.uk

Golde, Todd E ; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, Gainesville, FL, USA. tgolde@ufl.edu

HENEKA, Michael ; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany. michael.heneka@ukbonn.de ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. michael.heneka@ukbonn.de ; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA. michael.heneka@ukbonn.de

Readhead, Ben ; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. ben.readhead@asu.edu

External co-authors :

yes

Language :

English

Title :

Do infections have a role in the pathogenesis of Alzheimer disease?

Publication date :

April 2020

Journal title :

Nature Reviews. Neurology

ISSN :

1759-4758

eISSN :

1759-4766

Publisher :

Nature Research, England

Volume :

16

Issue :

4

Pages :

193 - 197

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.nature.com/articles/s41582-020-0323-9.pdf

Funding text :

T.E.G. is a co-founder and is on the scientific advisory board (SAB) of Lacerta Therapeutics. He is an SAB member for Promis Therapeutics and has served on SABs for Abbvie, Pfizer, Novartis, Roche/Genetic, Bristol Myers Squibb, Eli Lilly and Biogen. He is an inventor on a number of patents relating to Alzheimer disease therapeutics. He receives funding from the NIH, the Facial Pain Research Foundation and the State of Florida. M.T.H. serves as an advisory board member for IFM Therapeutics, Alector and Tiaki. The other authors declare no competing interests.

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Bibliography

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