Interferon Type I; Animals; Inflammation; Mice; Mice, Inbred C57BL; Police; Microglia; Neuroscience (all); General Neuroscience
Abstract :
[en] Neuroinflammation is a common feature of aging and neurodegeneration. In this issue of Neuron, Mathur et al. (2017) report that the antiviral drug Ganciclovir induces an interferon type I response in microglia through activation of the STING pathway, inhibiting inflammation and leading to protection in a model of multiple sclerosis.
Disciplines :
Neurology
Author, co-author :
Tejera, Darío; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 53127 Bonn, Germany
HENEKA, Michael ; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 53127 Bonn, Germany. Electronic address: michael.heneka@ukbonn.de
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