[en] Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia. The neurodegenerative diseases disrupt connectivity within brain circuits affecting neuronal-neuronal, neuronal-glial and glial-glial contacts. In addition neurodegenerative processes trigger universal and conserved glial reactions represented by astrogliosis and microglial activation. The complex of recently acquired knowledge allows us to regard the neurodegenerative diseases as primarily gliodegenerative processes, in which glial cells determine the progression and outcome of neuropathological process.
Disciplines :
Neurology
Author, co-author :
HENEKA, Michael ; Klinische Neurowissenschaften, Klinik und Poliklinik für Neurologie, 53127 Bonn, Germany. michael.heneka@ukb.uni-bonn.de
Rodríguez, José J; IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain ; Institute of Experimental Medicine, ASCR, Prague, Czech Republic
Verkhratsky, Alexei; Department of Neurosciences, University of the Basque Country UPV/EHU, 48940, Leioa, Spain ; Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom ; Institute of Experimental Medicine, ASCR, Prague, Czech Republic ; The University of Manchester, Manchester, M13 9PT, United Kingdom
Authors research was supported by Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe ( 10-6789 ) and the Wilhelm Sander foundation ( 2006.001.1 ) grants to MTH; Alzheimer's Research Trust (UK) Programme Grant ( ART/PG2004A/1 ) to AV and JJR; National Institute of Health (NIH) grant to AV, Grant Agency of the Czech Republic ( GACR 309/09/1696 ) to JJR and ( GACR 305/08/1384 ) to AV.
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