[en] Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.
Disciplines :
Neurologie
Auteur, co-auteur :
HENEKA, Michael ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn, Bonn, Germany. michael.heneka@ukbonn.de ; German Center for Neurodegenerative Disease, Bonn, Germany. michael.heneka@ukbonn.de ; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. michael.heneka@ukbonn.de
Golenbock, Douglas; German Center for Neurodegenerative Disease, Bonn, Germany
Latz, Eicke; German Center for Neurodegenerative Disease, Bonn, Germany ; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, 01605, USA ; Institute for Innate Immunity, University of Bonn, Bonn, Germany
Morgan, Dave; Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, USA
Brown, Robert; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.
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