Alzheimer's disease; cortical thickness; entorhinal cortex; parahippocampal cortex; subjective cognitive decline; subjective memory impairment; Aged; Analysis of Variance; Cerebral Cortex/pathology; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Memory Disorders/pathology; Middle Aged; Cerebral Cortex; Memory Disorders; Neuroscience (all); Clinical Psychology; Geriatrics and Gerontology; Psychiatry and Mental Health; General Medicine; General Neuroscience
Abstract :
[en] Elderly individuals with subjective memory impairment (SMI) report memory decline, but perform within the age-, gender-, and education- adjusted normal range on neuropsychological tests. Longitudinal studies indicate SMI as a risk factor or early sign of Alzheimer's disease (AD). There is increasing evidence from neuroimaging that at the group level, subjects with SMI display evidence of AD related pathology. This study aimed to determine differences in cortical thickness between individuals with SMI and healthy control subjects (CO) using the FreeSurfer environment. 110 participants (41 SMI/69 CO) underwent structural 3D-T1 MR imaging. Cortical thickness values were compared between groups in predefined AD-related brain regions of the medial temporal lobe, namely the bilateral entorhinal cortex and bilateral parahippocampal cortex. Cortical thickness reduction was observed in the SMI group compared to controls in the left entorhinal cortex (p = 0.003). We interpret our findings as evidence of early AD-related brain changes in persons with SMI.
Disciplines :
Neurology
Author, co-author :
Meiberth, Dix; Department of Psychiatry, University of Bonn, Bonn, Germany
Scheef, Lukas; Department of Radiology, University of Bonn, Bonn, Germany
Wolfsgruber, Steffen; Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany
Boecker, Henning; Department of Radiology, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany
Block, Wolfgang; Department of Radiology, University of Bonn, Bonn, Germany
Träber, Frank; Department of Radiology, University of Bonn, Bonn, Germany
Erk, Susanne; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Charitéplatz, Berlin, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany Department of Neurology, University of Bonn, Bonn, Germany Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Bonn, Germany
Jacobi, Heike; Department of Psychiatry, University of Bonn, Bonn, Germany
Spottke, Annika; Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany
Walter, Henrik; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Charitéplatz, Berlin, Germany
Wagner, Michael; Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany
Hu, Xiaochen; Department of Psychiatry, University of Bonn, Bonn, Germany
Jessen, Frank; Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany
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