[en] Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained strength as human genetics and experimental data suggest key roles for inflammatory cells in AD pathogenesis. To review this topic, Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium: "Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD)." Participants considered current evidence for and against the hypothesis that AD could be caused or exacerbated by infection or commensal microbes. Discussion focused on connecting microglial transcriptional states to functional states, mouse models that better mimic human immunity, the potential involvement of inflammasome signaling, metabolic alterations, self-reactive T cells, gut microbes and fungal infections, and lessons learned from Covid-19 patients with neurologic symptoms. The content presented in the symposium, and major topics raised in discussions are reviewed in this summary of the proceedings.
Disciplines :
Neurology
Author, co-author :
Whitson, Heather E; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Busse Bldg Rm 3502, Durham, NC, 27710, USA ; Durham VA Medical Center, Geriatric Research Education and Clinical Center, 508 Fulton Street, Durham, NC, 27705, USA
Colton, Carol; Department of Neurology, Duke University School of Medicine, 3116 N Duke St, Durham, NM, 27704, USA
El Khoury, Joseph; Center for Immunology & Inflammatory Diseases, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA
Gate, David; The Ken & Ruth Davee Dept of Neurology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Ward 12-140, Chicago, IL 60611, USA
Goate, Alison; Dept of Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, One Gustave L. Levy Place, Box 1498, New York, NY, 10029-6574, USA
HENEKA, Michael ; Dept of Neurodegenerative Disease and Geriatric Psychiatry/Neurology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53127, Bonn, Germany
Kaddurah-Daouk, Rima; Dept of Psychiatry and Behavioral Sciences, Dept of Medicine, Duke Institute of Brain Sciences, Duke University School of Medicine, DUMC Box 3903, Blue Zone, South, Durham, NC, 27710, USA
Klein, Robyn S; Center for Neuroimmunology & Neuroinfectious Diseases, Depts of Medicine, Pathology & Immunology, and Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8015, St. Louis, MO, 63110, USA
Shinohara, Mari L; Dept of Immunology, Duke University School of Medicine, 207 Research Dr, Box 3010, Durham, NC, 27710, USA
Sisodia, Sangram; Dept of Neurobiology, University of Chicago, Abbott Memorial Hall, 947 East 58th St, MC 0928, Chicago, IL, 60637, USA
Spudich, Serena S; Dept of Neurology, Yale School of Medicine, PO Box 208018, New Haven, CT, 06520, USA
Stevens, Beth; F.M. Kirby Neurobiology Center, Children's Hospital Boston, 300 Longwood Ave, Center for Life Sciences 12th Floor, Boston, MA, 02115, USA
Tanzi, Rudolph; McCance Center for Brain Health, Massachusetts General Hospital, 114 16th St, Charlestown, MA, 02129, USA
Ting, Jenny P; Depts of Genetics, Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for Translational Immunology, UNC School of Medicine, 125 Mason Farm Road, 6th Floor Marsico Hall, Chapel Hill, NC, 27599-7290, USA
Garden, Gwenn; Dept of Neurology, UNC School of Medicine, Physicians Office Building, 170 Manning Drive, Campus Box 7025, Chapel Hill, NC, 27599-7025, USA
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