Microglia: You'll Never Walk Alone!

[en] In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS.

Disciplines :

Neurology

Author, co-author :

Villacampa, Nàdia; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud Straße 25, 53127 Bonn, Germany

HENEKA, Michael ; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud Straße 25, 53127 Bonn, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 53127 Bonn, Germany. Electronic address: michael.heneka@ukbonn.de

External co-authors :

yes

Language :

English

Title :

Microglia: You'll Never Walk Alone!

Publication date :

20 February 2018

Journal title :

Immunity

ISSN :

1074-7613

eISSN :

1097-4180

Publisher :

Cell Press, United States

Volume :

Issue :

Pages :

195 - 197

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S1074761318300451?httpAccept=text/xml

Available on ORBilu :

since 07 May 2024

Statistics

Number of views

34 (0 by Unilu)

Number of downloads

20 (0 by Unilu)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

WoS citations^™

Bibliography

Bandura, D.R., Baranov, V.I., Ornatsky, O.I., Antonov, A., Kinach, R., Lou, X., Pavlov, S., Vorobiev, S., Dick, J.E., Tanner, S.D., Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal. Chem. 81 (2009), 6813–6822.
Bechmann, I., Priller, J., Kovac, A., Böntert, M., Wehner, T., Klett, F.F., Bohsung, J., Stuschke, M., Dirnagl, U., Nitsch, R., Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur. J. Neurosci. 14 (2001), 1651–1658.
Mrdjen, D., Pavlovic, A., Hartmann, F.J., Schreiner, B., Utz, S.G., Leung, B.P., Lelios, I., Heppner, F.L., Kipnis, J., Merkler, D., Greter, M., Becher, B., High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity 48 (2018), 380–395 this issue.
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M.F., Conway, S.J., Ng, L.G., Stanley, E.R., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330 (2010), 841–845.
Greter, M., Heppner, F.L., Lemos, M.P., Odermatt, B.M., Goebels, N., Laufer, T., Noelle, R.J., Becher, B., Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11 (2005), 328–334.
Heneka, M.T., Kummer, M.P., Latz, E., Innate immune activation in neurodegenerative disease. Nat. Rev. Immunol. 14 (2014), 463–477.
Kipp, M., Nyamoya, S., Hochstrasser, T., Amor, S., Multiple sclerosis animal models: a clinical and histopathological perspective. Brain Pathol. 27 (2017), 123–137.
Prinz, M., Priller, J., Sisodia, S.S., Ransohoff, R.M., Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 14 (2011), 1227–1235.
Sarlus, H., Heneka, M.T., Microglia in Alzheimer's disease. J. Clin. Invest. 127 (2017), 3240–3249.
Sie, C., Korn, T., Dendritic cells in central nervous system autoimmunity. Semin. Immunopathol. 39 (2017), 99–111.