Radiopharmaceuticals; Norepinephrine; Alzheimer Disease/diagnostic imaging; Alzheimer Disease/metabolism; Animals; Brain/diagnostic imaging; Brain/metabolism; Humans; Mice; Norepinephrine/metabolism; Plaque, Amyloid/metabolism; Positron-Emission Tomography/methods; Radiopharmaceuticals/pharmacokinetics; Disease Models, Animal; Molecular Probe Techniques; μPET; AD; Molecular imaging; Mouse models; Radiology, Nuclear Medicine and Imaging; mu PET; General Medicine
Résumé :
[en] Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the dynamics of changes on the molecular level. IMAGING OF AD CHARACTERISTIC CHANGES BY microPET: The imaging technology being employed includes magnetic resonance imaging (MRI) and nuclear imaging as well as optical-based imaging technologies. These imaging modalities are employed together or alone for disease phenotyping, development of imaging-guided therapeutic strategies and in basic and translational research. In this study, we review recent investigations employing positron emission tomography and MRI for phenotyping mouse models of Alzheimer's disease by imaging. We demonstrate that imaging has an important role in the characterization of mouse models of neurodegenerative diseases.
Disciplines :
Neurologie
Auteur, co-auteur :
Winkeler, A; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, and the Faculty of Medicine, University of Cologne, Gleuelerstrasse 50, Cologne, Germany
Waerzeggers, Y; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Inst. for Neurol. Res. with Klaus-Joachim-Zulch-Laboratories of the Max Planck Society, Faculty of Medicine of the University of Cologne, 50931 Cologne, Germany ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
Klose, A; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Inst. for Neurol. Res. with Klaus-Joachim-Zulch-Laboratories of the Max Planck Society, Faculty of Medicine of the University of Cologne, 50931 Cologne, Germany ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
Monfared, P; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Inst. for Neurol. Res. with Klaus-Joachim-Zulch-Laboratories of the Max Planck Society, Faculty of Medicine of the University of Cologne, 50931 Cologne, Germany ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
Thomas, A V; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Inst. for Neurol. Res. with Klaus-Joachim-Zulch-Laboratories of the Max Planck Society, Faculty of Medicine of the University of Cologne, 50931 Cologne, Germany ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
Schubert, M; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
HENEKA, Michael ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany ; Department of Neurology, University of Muenster, Münster, Germany
Jacobs, A H; Laboratory for Gene Therapy and Molecular Imaging, Max Planck Inst. for Neurol. Res. with Klaus-Joachim-Zulch-Laboratories of the Max Planck Society, Faculty of Medicine of the University of Cologne, 50931 Cologne, Germany ; Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease.
Date de publication/diffusion :
mars 2008
Titre du périodique :
European Journal of Nuclear Medicine and Molecular Imaging
ISSN :
1619-7070
eISSN :
1619-7089
Maison d'édition :
Springer Science and Business Media LLC, Allemagne
Acknowledgements Our work is supported in part by the Deutsche Forschungsgemeinschaft (DFG-Ja98/1-2), Center for Molecular Medicine Cologne (CMMC-C5), 6th FW EU grants EMIL (LSHC-CT-2004-503569) and DiMI (LSHB-CT-2005-512146).
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