[en] [en] BACKGROUND: Subjective cognitive decline (SCD) has been proposed as a pre-MCI at-risk condition of Alzheimer's disease (AD). Current research is focusing on a refined assessment of specific SCD features associated with increased risk for AD, as proposed in the SCD-plus criteria. We developed a structured interview (SCD-I) for the assessment of these features and tested their relationship with AD biomarkers.
METHODS: We analyzed data of 205 cognitively normal participants of the DELCODE study (mean age = 68.9 years; 52% female) with available CSF AD biomarkers (Aß-42, p-Tau181, Aß-42/Tau ratio, total Tau). For each of five cognitive domains (including memory, language, attention, planning, others), a study physician asked participants about the following SCD-plus features: the presence of subjective decline, associated worries, onset of SCD, feeling of worse performance than others of the same age group, and informant confirmation. We compared AD biomarkers of subjects endorsing each of these questions with those who did not, controlling for age. SCD was also quantified by two summary scores: the number of fulfilled SCD-plus features, and the number of domains with experienced decline. Covariate-adjusted linear regression analyses were used to test whether these SCD scores predicted abnormality in AD biomarkers.
RESULTS: Lower Aß-42 levels were associated with a reported decline in memory and language abilities, and with the following SCD-plus features: onset of subjective decline within 5 years, confirmation of cognitive decline by an informant, and decline-related worries. Furthermore, both quantitative SCD scores were associated with lower Aß42 and lower Aß42/Tau ratio, but not with total Tau or p-Tau181.
CONCLUSIONS: Findings support the usefulness of a criterion-based interview approach to assess and quantify SCD in the context of AD and validate the current SCD-plus features as predictors of AD pathology. While some features seem to be more closely associated with AD biomarkers than others, aggregated scores over several SCD-plus features or SCD domains may be the best predictors of AD pathology.
Disciplines :
Neurology
Author, co-author :
Miebach, Lisa; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany. Lisa.Miebach@ukbonn.de ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany. Lisa.Miebach@ukbonn.de
Wolfsgruber, Steffen; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Polcher, Alexandra; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Peters, Oliver; Institute of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Menne, Felix; Institute of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Luther, Katja; Institute of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany
Incesoy, Enise; Institute of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany
Priller, Josef; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany
Spruth, Eike; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany
Altenstein, Slawek; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany
Buerger, Katharina; Institute for Stroke and Dementia Research (ISD), LMU Munich, Munich, Germany ; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Catak, Cihan; Institute for Stroke and Dementia Research (ISD), LMU Munich, Munich, Germany
Janowitz, Daniel; Institute for Stroke and Dementia Research (ISD), LMU Munich, Munich, Germany
Perneczky, Robert; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany ; Ludwig-Maximilians-Universität München, Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany ; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK
Utecht, Julia; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany ; Ludwig-Maximilians-Universität München, Munich, Germany
Laske, Christoph; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany ; Hertie-Institute for Clinical Brain Research, Tübingen, Germany
Buchmann, Martina; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany ; Hertie-Institute for Clinical Brain Research, Tübingen, Germany
Schneider, Anja; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Fliessbach, Klaus; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Kalbhen, Pascal; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Brosseron, Frederic; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Spottke, Annika; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department of Neurology, University of Bonn, Bonn, Germany
Roy, Nina; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
Teipel, Stefan J; Department of Psychosomatic Medicine, University of Medicine, Rostock, Germany ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany
Kilimann, Ingo; Department of Psychosomatic Medicine, University of Medicine, Rostock, Germany ; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany
Wiltfang, Jens; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany ; Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany
Bartels, Claudia; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany ; Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany
Düzel, Emrah; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Dobisch, Laura; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Metzger, Coraline; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany ; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany
Meiberth, Dix; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany
Ramirez, Alfredo; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany
Jessen, Frank; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany
Wagner, Michael; German Center for Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG Neuropsychologie, Sigmund-Freud-Str. 27, 53127, Bonn, Germany ; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 27, 53127, Bonn, Germany
The study was funded by the German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE), reference number BN012.
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