Cognitive decline; Early diagnosing; Magnetic resonance imaging; Pattern recognition; Prediction; Subjective memory impairment; Aged; Atrophy/etiology; Atrophy/pathology; Brain/pathology; Cognition Disorders/diagnosis; Cognition Disorders/etiology; Cross-Sectional Studies; Female; Humans; Imaging, Three-Dimensional; Longitudinal Studies; Magnetic Resonance Imaging; Male; Memory Disorders/complications; Memory Disorders/pathology; Middle Aged; Neuropsychological Tests; ROC Curve; Support Vector Machine; Epidemiology; Health Policy; Developmental Neuroscience; Neurology (clinical); Geriatrics and Gerontology; Psychiatry and Mental Health; Cellular and Molecular Neuroscience
Abstract :
[en] BACKGROUND: Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI.
METHODS: We used a discriminative function (a support vector machine) trained on an independent data set of 226 healthy control subjects and 191 patients with probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns of 24 individuals with SMI and 53 control subjects. We tested for associations of these gray matter patterns with SMI presence, cognitive performance at baseline, and cognitive decline at follow-up.
RESULTS: Individuals with SMI showed greater similarity to an AD gray matter pattern compared with control subjects without SMI. In addition, episodic memory decline was associated with an AD gray matter pattern in the SMI group.
CONCLUSIONS: Our results indicate a link between the gray matter atrophy pattern of patients with AD and the presence of SMI. Furthermore, multivariate pattern recognition approaches seem to be a sensitive method for identifying subtle brain changes that correspond to future memory decline in SMI.
Disciplines :
Neurology
Author, co-author :
Peter, Jessica; Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany, Department of Neurology, University Medical Center Freiburg, Freiburg, Germany, Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany. Electronic address: jessica.peter@uniklinik-freiburg.de
Scheef, Lukas; Department of Radiology, University Hospital Bonn, Bonn, Germany
Abdulkadir, Ahmed; Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany, Group of Pattern Recognition and Image Processing, Department of Computer Science, University of Freiburg, Freiburg, Germany
Boecker, Henning; Department of Radiology, University Hospital Bonn, Bonn, Germany, German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany
HENEKA, Michael ; German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany, Department of Neurology, University of Bonn, Bonn, Germany, Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Bonn, Germany
Wagner, Michael; Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany, German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany
Koppara, Alexander; Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany
Klöppel, Stefan; Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany, Department of Neurology, University Medical Center Freiburg, Freiburg, Germany, Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, University Medical Center Freiburg, Freiburg, Germany
Jessen, Frank; Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany, German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany
Alzheimer's Disease Neuroimaging Initiative
External co-authors :
yes
Language :
English
Title :
Gray matter atrophy pattern in elderly with subjective memory impairment.
Publication date :
January 2014
Journal title :
Alzheimer's and Dementia: the Journal of the Alzheimer's Association
This work was supported by the Deutsche Forschungsgemeinschaft ( KL 2415/2-1 ), the Dr. Kübler-Chicken Foundation of the University of Freiburg , the Alzheimer Forschungsinitiative , and the German Competence Network on Dementia funded by the German Federal Ministry for Education and Research (grant O1GI 0102 ).
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