Toward a realistic model of multilayered bacterial colonies

[en] Bacteria are prolific at colonizing diverse surfaces under a widerange of environmental conditions, and exhibit fascinating examples of self-organization across scales. Though it has recently attracted considerable interest, the role of mechanical forces in the collective behavior of bacterial colonies is not yet fully understood. Here, we construct a model of growing rod-like bacteria, such as Escherichia coli based purely on mechanical forces. We perform overdamped molecular dynamics simulations of the colony starting from a few cells in contact with a surface. As the colony grows, microdomains of strongly aligned cells grow and proliferate. Our model captures both the initial growth of a bacterial colony and also shows characteristic signs of capturing the experimentally observed transition to multilayered colonies over longer timescales. We compare our results with experiments on E. coli cells and analyze the statistics of microdomains.

Disciplines :

Physics

Author, co-author :

Khan, M. T.

Cammann, J.

SENGUPTA, Anupam ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)

Renzi, E.

Mazza, M. G.

External co-authors :

yes

Language :

English

Title :

Toward a realistic model of multilayered bacterial colonies

Publication date :

21 March 2024

Journal title :

Condensed Matter Physics

ISSN :

1607-324X

eISSN :

2224-9079

Publisher :

Institute for Condensed Matter Physics of the National Academy of Sciences of Ukraine, Ukraine

Peer reviewed :

Peer Reviewed verified by ORBi

Focus Area :

Physics and Materials Science

Development Goals :

15. Life on land
3. Good health and well-being

Additional URL :

https://arxiv.org/pdf/2403.14855.pdf

FnR Project :

FNR11572821 - Biophysics Of Microbial Adaptation To Fluctuations In The Environment, 2017 (15/05/2018-14/05/2023) - Anupam Sengupta
FNR13719464 - Topological Fluid Mechanics: Decoding Emergent Dynamics In Anisotropic Fluids And Living Systems, 2019 (01/09/2020-31/08/2023) - Anupam Sengupta

Funders :

FNR - Fonds National de la Recherche
EPSRC - Engineering and Physical Sciences Research Council

Funding number :

Grant no. A17/MS/11572821/MBRACE; C19/MS/13719464/TOPOFLUME/Sengupta; AUDACITY Grant: IAS-20/CAMEOS; EP/S515140/1; EP/W522569/1

Funding text :

This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/S515140/1 for Loughborough University National Productivity Investment Fund (NPIF) 2018. J.C. and M.G.M. gratefully acknowledge EPSRC grant EP/W522569/1. A.S. thanks the Institute for Advanced Studies, University of Luxembourg (AUDACITY Grant: IAS-20/CAMEOS) and the Luxembourg National Research Fund’s ATTRACT Investigator Grant (Grant no. A17/MS/11572821/MBRACE) and CORE Grant (C19/MS/13719464/TOPOFLUME/Sengupta) for supporting this work.

Commentary :

8 pages, 5 figures

Available on ORBilu :

since 25 March 2024

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