Forensic DNA Phenotyping: a review on SNP Panels, Genotyping Techniques, and Prediction Models

Terrado-Ortuño, Nuria; MAY, Patrick

doi:10.1093/fsr/owae013

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Forensic DNA Phenotyping: a review on SNP Panels, Genotyping Techniques, and Prediction Models

Terrado-Ortuño, Nuria; MAY, Patrick

2024 • In Forensic Sciences Research, owae013

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https://hdl.handle.net/10993/60574

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10.1093/fsr/owae013

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Keywords :

Forensic genetics; DNA phenotyping; Genotyping

Abstract :

[en] In the past few years, forensic DNA phenotyping has attracted a strong interest in the forensic research. Among the increasing publications, many have focused on testing the available panels to infer biogeographical ancestry on less represented populations and understanding the genetic mechanisms underlying externally visible characteristics. However, there are currently no publications that gather all the existing panels limited to forensic DNA phenotyping and discuss the main technical limitations of the technique. In this review, we performed a bibliographic search in Scopus database of phenotyping-related literature, which resulted in a total of 48, 43 and 15 panels for biogeographical ancestry, externally visible characteristics and both traits inference, respectively. Here we provide a list of commercial and non-commercial panels and the limitations regarding the lack of harmonization in terms of terminology (i.e., categorization and measurement of traits) and reporting, the lack of genetic knowledge and environment influence to select markers and develop panels, and the debate surrounding the selection of genotyping technologies and prediction models and algorithms. In conclusion, this review aims to be an updated guide and to present an overview of the current related literature.

Research center :

Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)

Precision for document type :

Review article

Disciplines :

Genetics & genetic processes
Criminology

Author, co-author :

Terrado-Ortuño, Nuria; Genome Analysis, Bioinformatics Core, Luxembourg Centre for Systems Biomedicine , Esch-sur-Alzette, Luxembourg

MAY, Patrick ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core ; Genome Analysis, Bioinformatics Core, Luxembourg Centre for Systems Biomedicine , Esch-sur-Alzette, Luxembourg

External co-authors :

Language :

English

Title :

Forensic DNA Phenotyping: a review on SNP Panels, Genotyping Techniques, and Prediction Models

Publication date :

11 March 2024

Journal title :

Forensic Sciences Research

ISSN :

2096-1790

eISSN :

2471-1411

Publisher :

Oxford University Press (OUP)

Volume :

owae013

Peer reviewed :

Peer Reviewed verified by ORBi

Focus Area :

Law / European Law
Systems Biomedicine

Development Goals :

4. Quality education

Additional URL :

https://academic.oup.com/fsr/advance-article/doi/10.1093/fsr/owae013/7625515

Name of the research project :

U-AGR-6005 - IAS CRIMTYP - ALLEGREZZA Silvia

Funders :

Institute of Advanced Studies
Unilu - University of Luxembourg

Funding number :

U-AGR-6005

Funding text :

This work was supported by the Institute of Advanced Studies (University of Luxembourg) under an Audacity grant (AUDACITY-2020): Meet the Unknown: The Future of CRIMinal Forensic Genomics PhenoTYPing (CRIMTYP).

Available on ORBilu :

since 14 March 2024

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