Databases for lncRNAs: a comparative evaluation of emerging tools.

RNA, Long Noncoding; Computational Biology/methods; Databases, Genetic; Humans; Neoplasms/genetics; RNA, Long Noncoding/genetics/metabolism; Transcriptome; databases; lncRNAs; noncoding RNAs

Résumé :

[en] The vast majority of the human transcriptome does not code for proteins. Advances in transcriptome arrays and deep sequencing are giving rise to a fast accumulation of large data sets, particularly of long noncoding RNAs (lncRNAs). Although it is clear that individual lncRNAs may play important and diverse biological roles, there is a large gap between the number of existing lncRNAs and their known relation to molecular/cellular function. This and related information have recently been gathered in several databases dedicated to lncRNA research. Here, we review the content of general and more specialized databases on lncRNAs. We evaluate these resources in terms of the quality of annotations, the reporting of validated or predicted molecular associations, and their integration with other resources and computational analysis tools. We illustrate our findings using known and novel cancer-related lncRNAs. Finally, we discuss limitations and highlight potential future directions for these databases to help delineating functions associated with lncRNAs.

Disciplines :

Oncologie

Auteur, co-auteur :

FRITAH, Sabrina ; NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg L-1526, Luxembourg.

NICLOU, Simone P. ; NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg L-1526, Luxembourg.

AZUAJE, Francisco ; NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg L-1526, Luxembourg francisco.azuaje@crp-sante.lu.

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Databases for lncRNAs: a comparative evaluation of emerging tools.

Date de publication/diffusion :

novembre 2014

Titre du périodique :

RNA

ISSN :

1355-8382

eISSN :

1469-9001

Maison d'édition :

Cold Spring Harbor Laboratory Press, Etats-Unis

Volume/Tome :

Fascicule/Saison :

Pagination :

1655-65

Peer reviewed :

Peer reviewed vérifié par ORBi

Commentaire :

Disponible sur ORBilu :

depuis le 26 février 2024

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Nombre de vues

48 (dont 1 Unilu)

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59 (dont 0 Unilu)

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