Therapeutic control and resistance of the EGFR-driven signaling network in  glioblastoma.

EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (ErbB Receptors); Animals; Drug Resistance, Neoplasm; ErbB Receptors/genetics/metabolism; Glioblastoma/genetics/metabolism/pathology/therapy; Humans; Signal Transduction

Résumé :

[en] The alteration of the epidermal growth factor receptor (EGFR)-driven signaling network is a characteristic feature of glioblastomas (GBM), and its inhibition represents a treatment strategy. However, EGFR-targeted interventions have been largely ineffective. Complex perturbations in this system are likely to be central to tumor cells with high adaptive capacity and resistance to therapies. We review key concepts and mechanisms relevant to EGFR-targeted treatment resistance at a systems level. Our understanding of treatment resistance as a systems-level phenomenon is necessary to develop effective therapeutic options for GBM patients. This is allowing us to go beyond the notion of therapeutic targets as single molecular components, into strategies that can weaken cancer signaling robustness and boost inherent network-level vulnerabilities.

Disciplines :

Oncologie

Auteur, co-auteur :

AZUAJE, Francisco ; Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg. Francisco.Azuaje@lih.lu.

Tiemann, Katja; Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg. Katja.Tiemann@lih.lu.

NICLOU, Simone P. ; Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg. Simone.Niclou@lih.lu.

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.

Date de publication/diffusion :

31 mars 2015

Titre du périodique :

Cell Communication and Signaling

eISSN :

1478-811X

Maison d'édition :

BioMed Central, London, Royaume-Uni

Volume/Tome :

Pagination :

Peer reviewed :

Peer reviewed vérifié par ORBi

Disponible sur ORBilu :

depuis le 23 février 2024

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77 (dont 1 Unilu)

Nombre de téléchargements

18 (dont 0 Unilu)

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Bibliographie

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