In vivo models of primary brain tumors: pitfalls and perspectives.

[en] Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem cell-like cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.

Disciplines :

Oncology

Author, co-author :

Huszthy, Peter C; NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway.

Daphu, Inderjit

NICLOU, Simone P. ; NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway (P.C.H., I.D., H.M, F.T., R.B.), NorLux Neuro-Oncology Laboratory, Centre de Recherche Public de la Santé, Luxembourg (D.S., S.P.N., R.B.), Department of Pathology, Haukeland University Hospital, Bergen, Norway (H.M.)

Stieber, Daniel

Nigro, Janice M

Sakariassen, Per Ø

Miletic, Hrvoje

Thorsen, Frits

Bjerkvig, Rolf

External co-authors :

yes

Language :

English

Title :

In vivo models of primary brain tumors: pitfalls and perspectives.

Publication date :

August 2012

Journal title :

Neuro-Oncology

ISSN :

1522-8517

eISSN :

1523-5866

Publisher :

Oxford University Press

Volume :

Issue :

Pages :

979-93

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 21 February 2024

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Scopus citations^®

229

Scopus citations^®
without self-citations

216

OpenAlex citations

270

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