[en] Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem cell-like cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.
Disciplines :
Oncologie
Auteur, co-auteur :
Huszthy, Peter C; NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway.
Daphu, Inderjit
NICLOU, Simone P. ; NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway (P.C.H., I.D., H.M, F.T., R.B.), NorLux Neuro-Oncology Laboratory, Centre de Recherche Public de la Santé, Luxembourg (D.S., S.P.N., R.B.), Department of Pathology, Haukeland University Hospital, Bergen, Norway (H.M.)
Stieber, Daniel
Nigro, Janice M
Sakariassen, Per Ø
Miletic, Hrvoje
Thorsen, Frits
Bjerkvig, Rolf
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
In vivo models of primary brain tumors: pitfalls and perspectives.
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