The thrombin receptor in the nervous system.

Suidan, H S; NICLOU, Simone P.; Monard, D

doi:10.1055/s-2007-998999

No full text

Article (Scientific journals)

The thrombin receptor in the nervous system.

Suidan, H S; NICLOU, Simone P.; Monard, D

1996 • In Seminars in Thrombosis and Hemostasis, 22 (2), p. 125-33

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/10993/60255

DOI
10.1055/s-2007-998999

PubMed
8807708

Files (0)Send to Details Statistics Bibliography Similar publications

Files

Full Text

No document available.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Receptors, Thrombin; Animals; Astrocytes/cytology/metabolism; Mice; Nervous System/cytology/metabolism; Rats; Receptors, Thrombin/metabolism

Abstract :

[en] Neurite retraction and reversal of astrocyte stellation triggered by the serine protease thrombin are receptor-mediated events. This article summarizes the current knowledge about the cellular effects that are induced by thrombin and its receptor in neural cells. The data presented show that the thrombin receptor messenger RNA is expressed in cultured astrocytes and that the reversal of stellation caused by thrombin in these cells is prevented by the protein kinase inhibitor staurosporine. Peptides based in sequence on the tethered ligand domain of the thrombin receptor were shown to mimic the effect of thrombin in most systems investigated. Platelets of some species, however, aggregate only in response to thrombin but not to the peptides. This observation is confirmed here. Rodent receptor-activating peptides did not cause aggregation of rat or mouse platelets. In contrast, all peptides triggered reversal of stellation in rat astrocytes and neurite retraction in mouse neuroblastoma cells, supporting the proposed mechanism of cleavage-induced receptor activation in neural cells. Finally, evidence is presented that serum withdrawal causes a decrease in the amount of the thrombin receptor mRNA in different types of neuronal cells. The possible role played by the thrombin receptor in the nervous system is discussed.

Disciplines :

Oncology

Author, co-author :

Suidan, H S; Friedrich Miescher-Institut, Basel, Switzerland.

NICLOU, Simone P. ; the Friedrich Miescher-Institut, Basel, Switzerland

Monard, D

External co-authors :

yes

Language :

English

Title :

The thrombin receptor in the nervous system.

Publication date :

1996

Journal title :

Seminars in Thrombosis and Hemostasis

ISSN :

0094-6176

eISSN :

1098-9064

Publisher :

Thieme Medical Publishers, United States - New York

Volume :

Issue :

Pages :

125-33

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 19 February 2024

Statistics

Number of views

82 (1 by Unilu)

Number of downloads

0 (0 by Unilu)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Krystosek A, NW Seeds: Plasminogen activator release at the neuronal growth cone. Science 213:1532-1534, 1981.
Krystosek A, NW Seeds: Plasminogen activator secretion by granule neurons in cultures of developing cerebellum. Proc Natl Acad Sci USA 78:7810-7814, 1981.
Patterson PH: On the role of proteases, their inhibitors and the extracellular matrix in promoting neurite outgrowth. J Physiol 80: 207-211, 1985.
Monard D: Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. Trends Neurosci 11:541-544, 1988.
Pittman RN, JK Ivins, HM Buettner: Neuronal plasminogen activators: Cell surface binding sites and involvement in neurite out-growth. J Neurosci 9:4269-4286, 1989.
Gloor S, K Odink, J Guenther, H Nick, D Monard: A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. Cell 47:687-693, 1986.
Monard D, F Solomon, M. Rentsch, R Gysin: Glia-induced morphological differentiation in neuroblastoma cells. Proc Natl Acad Sci USA 70:1894-1897, 1973.
Zurn AD, H Nick, D Monard: A glia-derived nexin promotes neurite outgrowth in cultured chick sympathetic neurons. Dev Neurosci 10:17-24, 1988.
Farmer L, J Sommer, D Monard: Glia-derived nexin potentiates neurite extension in hippocampal pyramidal cells in vitro. Dev Neurosci 12:73-80, 1990.
Monard D, E Niday, A Limat, F Solomon: Inhibition of protease activity can lead to neurite extension in neuroblastoma cells. Prog Brain Res 58:359-364, 1983.
Gurwitz D, DD Cunningham: Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc Natl Acad Sci USA 85: 3440-3444, 1988.
Gurwitz D, DD Cunningham: Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition. J Cell Physiol 142:155-162, 1990.
Cavanaugh KP, D Gurwitz, DD Cunningham, RA Bradshaw: Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J Neurochem 54:1735-1743, 1990.
Nelson RB, R Siman: Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro. Brain Res Dev Brain Res 54:93-104, 1990.
Tas PW, K Koschel: Thrombin reverts the β-adrenergic agonist-induced morphological response in rat glioma C6 cells. Exp Cell Res 189:22-27, 1990.
Mazzoni IE, RL Kenigsberg: Thrombin indirectly affects cholinergic cell expression in primary septal cell cultures in a manner distinct from nerve growth factor. Neuroscience 45:195-204, 1991.
Hawkins RL, NW Seeds: Effect of proteases and their inhibitors on neurite outgrowth from neonatal mouse sensory ganglia in culture. Brain Res 398:63-70, 1986.
Baird JL, JA Raper: A serine proteinase involved in contact mediated repulsion of retinal growth cones by DRG neurites. J Neurosci 15:6605-6618, 1995.
Hawkins RL, NW Seeds: Protease inhibitors influence the direction of neurite outgrowth. Brain Res Dev Brain Res 45:203-209, 1989.
Snider RM, E Richelson: Thrombin stimulation of guanosine 3′,5′-monophosphate formation in murine neuroblastoma cells (clone NIE-115). Science 221:566-568, 1983.
Snider RM, M McKinney, JW Fenton II, E Richelson: Activation of cyclic nucleotide formation in murine neuroblastoma NIE-115 cells by modified human thrombins. J Biol Chem 259:9078-9081, 1984.
Perraud F, F Besnard, M Sensenbrenner, G Labourdette: Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture. Int J Dev Neurosci 5:181-188, 1987.
Neveu I, F Jehan, M Jandrot-Perrus, D Wion, P Brachet: Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: A possible involvement of thrombin. J Neurochem 60:858-867, 1993.
Vaughan PJ, CJ Pike, CW Cotman, DD Cunningham: Thromhin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci 15:5389-5401, 1995.
Smith-Swintosky VL, S Zimmer, JW Fenton, MP Mattson: Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury. J Neurosci 15:5840-5850, 1995.
Vu T-KH, DT Hung, VI Wheaton, SR Coughlin: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068, 1991.
Rasmussen UB, V Vouret-Craviari, S Jallat, Y Schlesinger, G Pages, A Pavirani, JP Lecocq, J Pouysségur, E Van Obberghen-Schilling: cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 288:123-128, 1991.
Zhong C, DJ Hayzer, MA Corson, MS Runge: Molecular cloning of the rat vascular smooth muscle thrombin receptor. Evidence for in vitro regulation by basic fibroblast growth factor. J Biol Chem 267:16975-16979, 1992.
Vu T-KH, VI Wheaton, DT Hung, I Charo, SR Coughlin: Domains specifying thrombin-receptor interaction. Nature 353:674-677, 1991.
Gerszten RE, J Chen, M Ishii, K Ishii, L Wang, T Nanevicz, CW Turck, T-KH Vu, SR Coughlin: Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature 368:648-651, 1994.
Suidan HS, SR Stone, BA Hemmings, D Monard: Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron 8:363-375, 1992.
Jalink K, WH Moolenaar: Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers. J Cell Biol 118:411-419, 1992.
Suidan HS, D Monard: How does thrombin cause neurite retraction? In: Fedoroff S, BHJ Juurlink, R Doucettes (Eds): Biology and Pathology of Astrocyte-Neuron Interaction. Plenum Press, New York, 1993, pp 181-191.
Beecher KL, TT Andersen, JW Fenton II, BW Festoff: Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. J Neurosci Res 37:108-115, 1994.
Herrick-Davis K, G Camussi, F Bussolino, C Baglioni: Modulation of neurite outgrowth in neuroblastoma cells by protein kinase C and platelet-activating factor. J Biol Chem 266:18620-18625, 1991.
Jalink K, EJ van Corven, T Hengeveld, N Morii, S Narumiya, WH Moolenaar: Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol 126:801-810, 1994.
Suidan HS, J Bouvier, E Schaerer, SR Stone, D Monard, J Tschopp: Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. Proc Natl Acad Sci USA 91:8112-8116, 1994.
Kinlough-Rathbone RL, ML Rand, MA Packham: Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood 82:103-106, 1993.
Cook NS, HG Zerwes, C Tapparelli, M Powling, J Singh, R Metternich, A Hagenbach: Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood: Activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonists. Thromb Haemostas 70:531-539, 1993.
Tapparelli C, R Metternich, C Ehrhardt, M Zurini, G Claeson, MF Scully, SR Stone: In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor. J Biol Chem 268:4734-4741, 1993.
Connolly TM, C Coudra, DM Feng, JJ Cook, MT Stranieri, CF Reilly, RF Nutt, RJ Gould: Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides. Thromb Haemostas 72:627-633, 1994.
McKinney M, RM Snider, E Richelson: Thrombin binding to human brain and spinal cord. Mayo Clin Proc 58:829-831, 1983.
Means ED, DK Anderson: Thrombin interactions with central nervous system tissue and implications of these interactions. Ann NY Acad Sci 485:314-322, 1986.
Soifer SJ, KG Peters, J O'Keefe, SR Coughlin: Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol 144:60-69, 1994.
Niclou S, HS Suidan, M Brown-Luedi, D Monard: Expression of the thrombin receptor mRNA in rat brain. Cell Mol Biol 40:421-428, 1994.
Weinstein JR, SJ Gold, DD Cunningham, CM Gall: Cellular localization of thrombin receptor mRNA in rat brain: Expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J Neurosci 15:2906-2919, 1995.
Dihanich M, M Kaser, E Reinhard, D Cunningham, D Monard: Prothrombin mRNA is expressed by cells of the nervous system. Neuron 6:575-581, 1991.
Deschepper CF, V Bigornia, ME Berens, MC Lapointe: Production of thrombin and antithrombin III by brain and astroglial cell cultures. Mol Brain Res 11:355-358, 1991.
Jamison CS, SJF Degen: Prenatal and postnatal expression of mRNA coding for rat prothrombin. Biochim Biophys Acta 1088: 208-216, 1991.
Grand RJ, PW Grabham, MJ Gallimore, PH Gallimore: Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: Independence from blood coagulation. EMBO J 8:2209-2215, 1989.
Grabham PW, RJ Grand, PH Gallimore: Purification of a serum factor which reverses dibutyryl cAMP induced differentiation. Cell Signal 1:269-281, 1989.
Nelken NA, SJ Soifer, KJ O, T-KH Vu, IF Charo, SR Coughlin: Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 90:1614-1621, 1992.
Liu Y, RD Fields, BW Festoff, PG Nelson: Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction. Proc Natl Acad Sci USA 91:10300-10304, 1994.
Ogino Y, T Costa: Thrombin is the major serum factor stimulating phosphoinositide turnover, but not DNA synthesis in human neuroblastoma SH-EP cells. Eur J Pharmacol 225:299-303, 1992.
Snider RM: Thrombin effects on cultured nerve cells: Clinical implications and evidence for a novel mechanism of neuronal activation. Ann NY Acad Sci 485:310-313, 1986.
Cunningham DD, L Pulliam, PJ Vaughan: Protease nexin-1 and thrombin: Injury-related processes in the brain. Thromb Haemostas 70:168-171, 1993.
Nishino A, M Suzuki, H Ohtani, O Motohashi, K Umezawa, H Nagura, T Yoshimoto: Thrombin may contribute to the pathophysiology of central nervous system injury. J Neurotrauma 10:167-179, 1993.
Nishino A, M Suzuki, T Yoshimoto, H Otani, H Nagura: A novel aspect of thrombin in the tissue reaction following central nervous system injury. Acta Neurochirur Suppl 60:86-88, 1994.
Wagner SL, JW Geddes, CW Cotman, AL Lau, D Gurwitz, PJ Isackson, DD Cunningham: Protease nexin-1, an antithrombin with neunte outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci USA 86:8284-8288, 1989.
Akiyama H, K Ikeda, H Kondo, PL McGeer: Thrombin accumulation in brains of patients with Alzheimer's disease. Neurosci Lett 146:152-154, 1992.
Chong YH, JM Jung, W Choi, CW Park, KS Choi, YH Suh: Bacterial expression, purification of full length and carboxyl terminal fragment of Alzheimer amyloid precursor protein and their proteolytic processing by thrombin. Life Sci 54:1259-1268, 1994.
Chomczynski P, N Sacchi: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
Suidan HS, AM Tolkovsky: Simultaneous analysis of adenosine 3′,5′-cyclic monophosphate accumulation and adenosine 5′-triphosphate metabolism in cultured cells preincubated with [2,3H]-adenine. Anal Biochem 205:159-165, 1992.