Humans; Big Data; Glioblastoma; Machine Learning; Rare Diseases; Information Dissemination
Abstract :
[en] Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.
Disciplines :
Oncology
Author, co-author :
Pati, Sarthak ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Informatics, Technical University of Munich, Munich, Bavaria, Germany.
Baid, Ujjwal ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edwards, Brandon ; Intel Corporation, Santa Clara, CA, USA.
Sheller, Micah; Intel Corporation, Santa Clara, CA, USA.
Wang, Shih-Han; Intel Corporation, Santa Clara, CA, USA.
Reina, G Anthony; Intel Corporation, Santa Clara, CA, USA.
Foley, Patrick ; Intel Corporation, Santa Clara, CA, USA.
Gruzdev, Alexey; Intel Corporation, Santa Clara, CA, USA.
Karkada, Deepthi ; Intel Corporation, Santa Clara, CA, USA.
Davatzikos, Christos ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sako, Chiharu ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ghodasara, Satyam ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bilello, Michel; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mohan, Suyash ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vollmuth, Philipp ; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Brugnara, Gianluca ; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Preetha, Chandrakanth J ; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Sahm, Felix ; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
Maier-Hein, Klaus ; Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany. ; Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Zenk, Maximilian ; Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.
Bendszus, Martin; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Wick, Wolfgang ; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany.
Calabrese, Evan ; Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Rudie, Jeffrey ; Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Villanueva-Meyer, Javier; Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Cha, Soonmee; Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Ingalhalikar, Madhura; Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.
Jadhav, Manali ; Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.
Pandey, Umang ; Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.
Saini, Jitender; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Garrett, John ; Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. ; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Larson, Matthew; Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Jeraj, Robert; Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. ; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Currie, Stuart ; Leeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.
Frood, Russell ; Leeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.
Fatania, Kavi ; Leeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.
Huang, Raymond Y; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chang, Ken; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Balaña, Carmen ; Catalan Institute of Oncology, Badalona, Spain.
Capellades, Jaume; Consorci MAR Parc de Salut de Barcelona, Catalonia, Spain.
Puig, Josep; Department of Radiology (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain.
Trenkler, Johannes ; Institute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.
Pichler, Josef; Department of Neurooncology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.
Necker, Georg ; Institute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.
Haunschmidt, Andreas ; Institute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.
Meckel, Stephan ; Institute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria. ; Institute of Diagnostic and Interventional Neuroradiology, RKH Klinikum Ludwigsburg, Ludwigsburg, Germany.
Shukla, Gaurav; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. ; Department of Radiation Oncology, Christiana Care Health System, Philadelphia, PA, USA.
Liem, Spencer; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
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Flanders, Adam E; Department of Radiology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Dicker, Adam P ; Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Sair, Haris I ; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; The Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jones, Craig K ; The Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Venkataraman, Archana ; Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jiang, Meirui ; The Chinese University of Hong Kong, Hong Kong, China.
So, Tiffany Y ; The Chinese University of Hong Kong, Hong Kong, China.
Chen, Cheng ; The Chinese University of Hong Kong, Hong Kong, China.
Heng, Pheng Ann; The Chinese University of Hong Kong, Hong Kong, China.
Dou, Qi; The Chinese University of Hong Kong, Hong Kong, China.
Kozubek, Michal ; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
Lux, Filip ; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
Michálek, Jan ; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
Matula, Petr ; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
Keřkovský, Miloš ; Department of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic.
Kopřivová, Tereza ; Department of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic.
Dostál, Marek ; Department of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic. ; Department of Biophysics, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Vybíhal, Václav ; Department of Neurosurgery, Faculty of Medicine, Masaryk University, Brno, and University Hospital and Czech Republic, Brno, Czech Republic.
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Mitchell, J Ross; University of Alberta, Edmonton, AB, Canada. ; Alberta Machine Intelligence Institute, Edmonton, AB, Canada.
Farinhas, Joaquim ; Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Maldjian, Joseph A; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yogananda, Chandan Ganesh Bangalore; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Pinho, Marco C; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Reddy, Divya; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Holcomb, James; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wagner, Benjamin C; University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ellingson, Benjamin M; UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. ; UCLA Neuro-Oncology Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CaA, USA.
Cloughesy, Timothy F ; UCLA Neuro-Oncology Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CaA, USA.
Raymond, Catalina; UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Oughourlian, Talia; UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. ; Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Hagiwara, Akifumi; Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Wang, Chencai ; Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
To, Minh-Son; College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia. ; Division of Surgery and Perioperative Medicine, Flinders Medical Centre, Bedford Park, SA, Australia.
Bhardwaj, Sargam; College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Chong, Chee; South Australia Medical Imaging, Flinders Medical Centre, Bedford Park, SA, Australia.
Agzarian, Marc ; South Australia Medical Imaging, Flinders Medical Centre, Bedford Park, SA, Australia. ; Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Falcão, Alexandre Xavier ; Institute of Computing, University of Campinas, Campinas, São Paulo, Brazil.
Martins, Samuel B ; Federal Institute of São Paulo, Campinas, São Paulo, Brazil.
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Sprenger, Flávia ; Department of Radiology, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Menotti, David ; Department of Informatics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Lucio, Diego R; Department of Informatics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
LaMontagne, Pamela ; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Marcus, Daniel; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Wiestler, Benedikt ; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ; TranslaTUM (Zentralinstitut für translationale Krebsforschung der Technischen Universität München), Klinikum rechts der Isar, Munich, Germany.
Kofler, Florian ; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ; TranslaTUM (Zentralinstitut für translationale Krebsforschung der Technischen Universität München), Klinikum rechts der Isar, Munich, Germany. ; Image-Based Biomedical Modeling, Department of Informatics, Technical University of Munich, Munich, Germany.
Ezhov, Ivan ; Department of Informatics, Technical University of Munich, Munich, Bavaria, Germany. ; TranslaTUM (Zentralinstitut für translationale Krebsforschung der Technischen Universität München), Klinikum rechts der Isar, Munich, Germany. ; Image-Based Biomedical Modeling, Department of Informatics, Technical University of Munich, Munich, Germany.
Metz, Marie ; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jain, Rajan ; Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA. ; Department of Neurosurgery, NYU Grossman School of Medicine, New York, NY, USA.
Lee, Matthew ; Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Lui, Yvonne W ; Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
McKinley, Richard ; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Slotboom, Johannes ; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Radojewski, Piotr; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Meier, Raphael; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Wiest, Roland ; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Murcia, Derrick; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Fu, Eric; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Haas, Rourke; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Thompson, John; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Ormond, David Ryan ; Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
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Vadmal, Vachan; Department of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Waite, Kristin ; National Cancer Institute, National Institute of Health, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
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Pei, Linmin; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ak, Murat ; Department of Radiology, Neuroradiology Division, University of Pittsburgh, Pittsburgh, PA, USA.
Srinivasan, Ashok; Department of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Bapuraj, J Rajiv ; Department of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Rao, Arvind; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Wang, Nicholas ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Yoshiaki, Ota; Department of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Moritani, Toshio; Department of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Turk, Sevcan; Department of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Lee, Joonsang ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Prabhudesai, Snehal; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Morón, Fanny ; Department of Radiology, Baylor College of Medicine, Houston, TX, USA.
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Glocker, Ben ; Department of Computing, Imperial College London, London, UK.
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Zampakis, Peter ; Department of NeuroRadiology, University of Patras, Patras, Greece.
Panagiotopoulos, Vasileios ; Department of Neurosurgery, University of Patras, Patras, Greece.
Tsiganos, Panagiotis ; Clinical Radiology Laboratory, Department of Medicine, University of Patras, Patras, Greece.
Alexiou, Sotiris; Department of Electrical and Computer Engineering, University of Patras, Patras, Greece.
Haliassos, Ilias ; Department of Neuro-Oncology, University of Patras, Patras, Greece.
Zacharaki, Evangelia I ; Department of Electrical and Computer Engineering, University of Patras, Patras, Greece.
Moustakas, Konstantinos ; Department of Electrical and Computer Engineering, University of Patras, Patras, Greece.
Kalogeropoulou, Christina ; Department of NeuroRadiology, University of Patras, Patras, Greece.
Kardamakis, Dimitrios M; Department of Radiation Oncology, University of Patras, Patras, Greece.
Choi, Yoon Seong ; Yonsei University College of Medicine, Seoul, Korea.
Lee, Seung-Koo ; Yonsei University College of Medicine, Seoul, Korea.
Chang, Jong Hee ; Yonsei University College of Medicine, Seoul, Korea.
Ahn, Sung Soo ; Yonsei University College of Medicine, Seoul, Korea.
Luo, Bing; Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Poisson, Laila ; Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
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Tiwari, Pallavi; Case Western Reserve University, Cleveland, OH, USA.
Verma, Ruchika; Alberta Machine Intelligence Institute, Edmonton, AB, Canada. ; Case Western Reserve University, Cleveland, OH, USA.
Bareja, Rohan; Case Western Reserve University, Cleveland, OH, USA.
Yadav, Ipsa; Case Western Reserve University, Cleveland, OH, USA.
Chen, Jonathan ; Case Western Reserve University, Cleveland, OH, USA.
Kumar, Neeraj ; University of Alberta, Edmonton, AB, Canada. ; Alberta Machine Intelligence Institute, Edmonton, AB, Canada.
Smits, Marion ; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
van der Voort, Sebastian R; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Alafandi, Ahmed; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Incekara, Fatih; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands. ; Department of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Wijnenga, Maarten M J; Department of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Kapsas, Georgios ; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Gahrmann, Renske ; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Schouten, Joost W; Department of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Dubbink, Hendrikus J ; Department of Pathology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Vincent, Arnaud J P E ; Department of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
van den Bent, Martin J ; Department of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
French, Pim J ; Department of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Klein, Stefan ; Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Yuan, Yading ; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sharma, Sonam; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tseng, Tzu-Chi; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adabi, Saba; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
NICLOU, Simone P. ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) ; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Keunen, Olivier ; Translation Radiomics, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Hau, Ann-Christin ; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg. ; Luxembourg Center of Neuropathology, Laboratoire National De Santé, Luxembourg, Luxembourg.
Vallières, Martin ; Department of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada. ; Centre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Fortin, David; Centre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, QC, Canada. ; Division of Neurosurgery and Neuro-Oncology, Faculty of Medicine and Health Science, Université de Sherbrooke, Sherbrooke, QC, Canada.
Lepage, Martin ; Centre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, QC, Canada. ; Department of Nuclear Medicine and Radiobiology, Sherbrooke Molecular Imaging Centre, Université de Sherbrooke, Sherbrooke, QC, Canada.
Landman, Bennett ; Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Ramadass, Karthik; Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Xu, Kaiwen ; Department of Computer Science, Vanderbilt University, Nashville, TN, USA.
Chotai, Silky; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Chambless, Lola B; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Mistry, Akshitkumar; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Thompson, Reid C; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Gusev, Yuriy ; Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Bhuvaneshwar, Krithika ; Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Sayah, Anousheh ; Division of Neuroradiology & Neurointerventional Radiology, Department of Radiology, MedStar Georgetown University Hospital, Washington, DC, USA.
Bencheqroun, Camelia; Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Belouali, Anas ; Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Madhavan, Subha; Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Booth, Thomas C ; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK. ; Department of Neuroradiology, Ruskin Wing, King's College Hospital NHS Foundation Trust, London, UK.
Chelliah, Alysha; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Modat, Marc; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Shuaib, Haris ; Stoke Mandeville Hospital, Mandeville Road, Aylesbury, UK. ; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Dragos, Carmen ; Stoke Mandeville Hospital, Mandeville Road, Aylesbury, UK.
Abayazeed, Aly; Neosoma Inc., Groton, MA, USA.
Kolodziej, Kenneth; Neosoma Inc., Groton, MA, USA.
Hill, Michael; Neosoma Inc., Groton, MA, USA.
Abbassy, Ahmed; University of Cairo School of Medicine, Giza, Egypt.
Gamal, Shady; University of Cairo School of Medicine, Giza, Egypt.
Mekhaimar, Mahmoud; University of Cairo School of Medicine, Giza, Egypt.
Qayati, Mohamed ; University of Cairo School of Medicine, Giza, Egypt.
Reyes, Mauricio ; University of Bern, Bern, Switzerland.
Park, Ji Eun; Department of Radiology, Asan Medical Center, Seoul, South Korea.
Yun, Jihye; Department of Radiology, Asan Medical Center, Seoul, South Korea.
Kim, Ho Sung ; Department of Radiology, Asan Medical Center, Seoul, South Korea.
Mahajan, Abhishek ; The Clatterbridge Cancer Centre NHS Foundation Trust Pembroke Place, Liverpool, UK.
Muzi, Mark ; Department of Radiology, University of Washington, Seattle, WA, USA.
Benson, Sean ; Netherlands Cancer Institute, Amsterdam, Netherlands.
Beets-Tan, Regina G H; Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands. ; GROW School of Oncology and Developmental Biology, Maastricht, Netherlands.
Teuwen, Jonas; Netherlands Cancer Institute, Amsterdam, Netherlands.
Herrera-Trujillo, Alejandro ; Clínica Imbanaco Grupo Quirón Salud, Cali, Colombia. ; Universidad del Valle, Cali, Colombia.
Trujillo, Maria; Universidad del Valle, Cali, Colombia.
Escobar, William; Clínica Imbanaco Grupo Quirón Salud, Cali, Colombia. ; Universidad del Valle, Cali, Colombia.
Abello, Ana; Universidad del Valle, Cali, Colombia.
Bernal, Jose ; Universidad del Valle, Cali, Colombia. ; The University of Edinburgh, Edinburgh, UK.
Gómez, Jhon; Universidad del Valle, Cali, Colombia.
Choi, Joseph; Department of Industrial and Systems Engineering, University of Iowa, Iowa, USA.
Baek, Stephen ; Department of Industrial and Systems Engineering, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Kim, Yusung; Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Ismael, Heba; Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Allen, Bryan ; Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Buatti, John M ; Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Kotrotsou, Aikaterini; MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
Li, Hongwei; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Weiss, Tobias ; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Weller, Michael ; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Bink, Andrea ; Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Pouymayou, Bertrand ; Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Shaykh, Hassan F; University of Alabama in Birmingham, Birmingham, AL, USA.
Saltz, Joel ; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.
Prasanna, Prateek; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.
Shrestha, Sampurna ; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.
Mani, Kartik M ; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA. ; Department of Radiation Oncology, Stony Brook University, Stony Brook, NY, USA.
Payne, David ; Department of Radiology, Stony Brook University, Stony Brook, NY, USA.
Kurc, Tahsin ; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA. ; Scientific Data Group, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Pelaez, Enrique ; Escuela Superior Politecnica del Litoral, Guayaquil, Guayas, Ecuador.
Franco-Maldonado, Heydy; Sociedad de Lucha Contral el Cancer - SOLCA, Guayaquil Ecuador, Guayaquil, Ecuador.
Loayza, Francis ; Escuela Superior Politecnica del Litoral, Guayaquil, Guayas, Ecuador.
Quevedo, Sebastian ; Universidad Católica de Cuenca, Cuenca, Ecuador.
Guevara, Pamela ; Universidad de Concepción, Concepción, Biobío, Chile.
Torche, Esteban; Universidad de Concepción, Concepción, Biobío, Chile.
Mendoza, Cristobal ; Universidad de Concepción, Concepción, Biobío, Chile.
Vera, Franco; Universidad de Concepción, Concepción, Biobío, Chile.
Ríos, Elvis ; Universidad de Concepción, Concepción, Biobío, Chile.
López, Eduardo ; Universidad de Concepción, Concepción, Biobío, Chile.
Velastin, Sergio A; School of Electronic Engineering and Computer Science, Queen Mary University of London, London, UK.
Ogbole, Godwin ; Department of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Soneye, Mayowa; Department of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Oyekunle, Dotun ; Department of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Odafe-Oyibotha, Olubunmi; Clinix Healthcare, Lagos, Lagos, Nigeria.
Osobu, Babatunde; Department of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Shu'aibu, Mustapha; Department of Radiology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.
Dorcas, Adeleye; Department of Radiology, Obafemi Awolowo University Ile-Ife, Ile-Ife, Osun, Nigeria.
Dako, Farouk ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ; Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Simpson, Amber L; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. ; School of Computing, Queen's University, Kingston, ON, Canada.
Hamghalam, Mohammad; School of Computing, Queen's University, Kingston, ON, Canada. ; Department of Electrical Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran.
Peoples, Jacob J ; School of Computing, Queen's University, Kingston, ON, Canada.
Hu, Ricky; School of Computing, Queen's University, Kingston, ON, Canada.
Tran, Anh ; School of Computing, Queen's University, Kingston, ON, Canada.
Cutler, Danielle ; The Faculty of Arts & Sciences, Queen's University, Kingston, ON, Canada.
Moraes, Fabio Y ; Department of Oncology, Queen's University, Kingston, ON, Canada.
Boss, Michael A ; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Gimpel, James ; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Veettil, Deepak Kattil ; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Schmidt, Kendall; Data Science Institute, American College of Radiology, Reston, VA, USA.
Bialecki, Brian ; Data Science Institute, American College of Radiology, Reston, VA, USA.
Marella, Sailaja; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Price, Cynthia; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Cimino, Lisa; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Apgar, Charles; Center for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Shah, Prashant ; Intel Corporation, Santa Clara, CA, USA.
Menze, Bjoern; Department of Informatics, Technical University of Munich, Munich, Bavaria, Germany. ; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Barnholtz-Sloan, Jill S ; National Cancer Institute, National Institute of Health, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA. ; Center for Biomedical Informatics and Information Technology, National Cancer Institute (NCI), National Institute of Health, Bethesda, MD, USA.
Martin, Jason ; Intel Corporation, Santa Clara, CA, USA.
Bakas, Spyridon ; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. sbakas@upenn.edu. ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. sbakas@upenn.edu. ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. sbakas@upenn.edu.
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