Neutrophil Extracellular Vesicles: A Delicate Balance between Pro-Inflammatory Responses and Anti-Inflammatory Therapies.

ZHOU, Yang; BRECHARD, Sabrina

doi:10.3390/cells11203318

Article (Scientific journals)

Neutrophil Extracellular Vesicles: A Delicate Balance between Pro-Inflammatory Responses and Anti-Inflammatory Therapies.

ZHOU, Yang; BRECHARD, Sabrina

2022 • In Cells, 11 (20), p. 3318

Peer Reviewed verified by ORBi

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https://hdl.handle.net/10993/60109

DOI
10.3390/cells11203318

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36291183

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Keywords :

extracellular vesicles; inflammation; neutrophils; therapy; Anti-Inflammatory Agents; Nucleic Acids; Lipids; Humans; Neutrophils/metabolism; Inflammation/metabolism; Anti-Inflammatory Agents/metabolism; Extracellular Vesicles/metabolism; Nucleic Acids/metabolism; Biochemistry, Genetics and Molecular Biology (all); General Medicine

Abstract :

[en] Extracellular vesicles (EVs) are released in the extracellular environment during cell activation or apoptosis. Working as signal transducers, EVs are important mediators of intercellular communication through the convoying of proteins, nucleic acids, lipids, and metabolites. Neutrophil extracellular vesicles (nEVs) contain molecules acting as key modulators of inflammation and immune responses. Due to their potential as therapeutic tools, studies about nEVs have been increasing in recent years. However, our knowledge about nEVs is still in its infancy. In this review, we summarize the current understanding of the role of nEVs in the framework of neutrophil inflammation functions and disease development. The therapeutic potential of nEVs as clinical treatment strategies is deeply discussed. Moreover, the promising research landscape of nEVs in the near future is also examined.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

ZHOU, Yang ; University of Luxembourg > Faculty of Science, Technology and Medicine > Department of Life Sciences and Medicine > Team Jean-Luc BUEB

BRECHARD, Sabrina ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

External co-authors :

Language :

English

Title :

Neutrophil Extracellular Vesicles: A Delicate Balance between Pro-Inflammatory Responses and Anti-Inflammatory Therapies.

Publication date :

21 October 2022

Journal title :

Cells

eISSN :

2073-4409

Publisher :

MDPI, Switzerland

Volume :

Issue :

Pages :

3318

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.mdpi.com/2073-4409/11/20/3318/pdf

Funders :

Fonds National de la Recherche

Funding text :

This work was supported by the University of Luxembourg and the Fonds National de la Recherche through the PRIDE/11012546/NEXTIMMUNE FNR-PRIDE Doctoral Training Unit program NEXTIMMUNE (PRIDE/11012546/NEXTIMMUNE).

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