Alzheimer’s disease; cognition; dementia prevention; healthy aging; mild cognitive impairment; multi-domain lifestyle interventions; neuropsychological assessment; personalized prevention; risk factor assessment; subjective cognitive decline; Psychiatry and Mental health; Geriatrics and Gerontology; Clinical Psychology; General Medicine; General Neuroscience
Abstract :
[en] BACKGROUND: With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from the development of causative treatments, the successful implementation of prevention strategies is of utmost importance to reduce the high societal burden caused by neurodegenerative diseases leading to dementia among which the most common cause is Alzheimer's disease.
OBJECTIVE: The aim of the Luxembourgish "programme dementia prevention (pdp)" is to prevent or at least delay dementia in an at-risk population through personalized multi-domain lifestyle interventions. The current work aims to provide a detailed overview of the methodology and presents initial results regarding the cohort characteristics and the implementation process.
METHODS: In the frame of the pdp, an extensive neuropsychological evaluation and risk factor assessment are conducted for each participant. Based on the results, individualized multi-domain lifestyle interventions are suggested.
RESULTS: A total number of 450 participants (Mean age = 69.5 years; SD = 10.8) have been screened at different recruitment sites throughout the country, among whom 425 participants (94.4%) met the selection criteria.
CONCLUSIONS: We provide evidence supporting the feasibility of implementing a nationwide dementia prevention program and achieving successful recruitment of the target population by establishing a network of different healthcare providers.
Disciplines :
Public health, health care sciences & services Neurology
SKROZIC, Amna ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg
ERZ, Dorothee ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg
KAYSEN, Anne ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Fritz, Joëlle V; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg
LOUREIRO, Joao Manuel ; University of Luxembourg ; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg
MCINTYRE, Deborah ; University of Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg
PAULY, Laure ; University of Luxembourg ; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg ; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg
KEMP, Jennifer ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Translational Neuroscience ; Department of Geriatrics, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg
SCHMITZ, Sabine Katharina ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Communication Office
WAGNER, Sophie ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Communication Office
SOARE-LELUBRE, Ruxandra ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > LCSB Operations > Communication Office
SATAGOPAM, Venkata ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Vega, Carlos; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg
GAWRON, Piotr ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Bioinformatics Core > Visualisation
Roomp, Kirsten; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg
Conde, Patricia Martins; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg
KLUCKEN, Jochen ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Digital Medicine ; Digital Medicine, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg ; Digital Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg
Köhler, Sebastian; Alzheimer Centrum Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands ; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
Hartmann, Tobias; Deutsches Institut für Demenz Prävention (DIDP), Medical Faculty, Saarland University, Homburg, Germany ; Department of Experimental Neurology, Saarland University, Homburg, Germany
Dodel, Richard; Chair of Geriatric Medicine, University Duisburg-Essen, Essen, Germany
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
Kalbe, Elke; Department of Medical Psychology | Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany
KRÜGER, Rejko ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
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