[en] [en] BACKGROUND: Information on determinants of patient-reported functional mobility is lacking but would inform the planning of healthcare, resources and strategies to promote functional mobility in people with Parkinson's disease (PD).
RESEARCH QUESTION: To identify the determinants of patient-reported functional mobility of people with PD.
METHODS: Eligible: Randomized Controlled Trials, cohort, case-control, or cross-sectional analyses in people PD without date or setting restrictions, published in English, German, or French. Excluded: instruments with under 50 % of items measuring mobility. On August 9th 2023 we last searched Medline, CINAHL and PsychInfo. We assessed risk of bias using the mixed-methods appraisal tool. Results were synthesized by tabulating the determinants by outcomes and study designs.
RESULTS: Eleven studies published 2012-2023 were included (most in Swedish outpatient settings). Samples ranged from 9 to 255 participants. Follow-up varied from 1.5 to 36 months with attrition of 15-42 %. Heterogenic study designs complicated results synthesis. However, determinants related to environment seem to associate the strongest with patient-reported functional mobility, although determinants related to body structures and functions were most investigated. We identified disease duration, the ability to drive, caregiving, sex, age, cognitive impairment, postural instability and social participation as determinants of patient-reported functional mobility.
DISCUSSION: Methodological quality of the studies was limited. No study reported an a priori power calculation. Three studies controlled for confounders. The included studies lack representativeness of the population of people living with PD. Standardized sets of outcomes could enable more systematic research synthesis.
CONCLUSIONS: Future research should focus on activities, participation and environmental factors and improve methodological quality.
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
KRÜGER, Rejko ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Zeegers, Maurice P ✱; Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+, Maastricht, the Netherlands, Department of Epidemiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands. Electronic address: m.zeegers@maastrichtuniversity.nl
McCrum, Christopher ✱; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands, Department of Rehabilitation Sciences, Neurorehabilitation Research Group, KU Leuven, Leuven, Belgium. Electronic address: Chris.mccrum@maastrichtuniversity.nl
NCER-PD consortium
✱ These authors have contributed equally to this work.
External co-authors :
yes
Language :
English
Title :
Determinants of patient-reported functional mobility in people with Parkinson's disease: A systematic review.
Tosserams, A., de Vries, N.M., Bloem, B.R., Nonnekes, J., Multidisciplinary care to optimize functional mobility in Parkinson disease. Clin. Geriatr. Med. 36:1 (2020), 159–172.
Muslimovic, D., Post, B., Speelman, J.D., Schmand, B., De Haan, R.J., Determinants of disability and quality of life in mild to moderate Parkinson disease. Neurology 70:23 (2008), 2241–2247, 10.1212/01.wnl.0000313835.33830.80.
Global Parkinson's Disease Survey (GPDS) Steering Committee, Factors impacting on quality of life in Parkinson's disease: results from an international survey. Mov. Disord. 17:1 (2002), 60–67, 10.1002/mds.10010.
Bouca-Machado, R., Maetzler, W., Ferreira, J.J., What is functional mobility applied to Parkinson's disease?. J. Park. Dis. 8:1 (2018), 121–130.
FDA, Guidance for Industry: Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims., (2009). 〈http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM193282.pdf〉.
B.C. Johnston, D.L. Patrick, T. Devji, L.J. Maxwell, C.O.B. III, D.E. Beaton, et al., Chapter 18: Patient-reported outcomes, in: Higgins J.P.T., Thomas J., Chandler J., Cumpston M., Li T., Page M.J., et al. (Eds.), Cochrane Handbook for Systematic Reviews of Interventions Version 6.3, Cochrane. 2022.
Lindh-Rengifo, M., Jonasson, S.B., Ullen, S., Mattsson-Carlgren, N., Nilsson, M.H., Perceived walking difficulties in Parkinson's disease - predictors and changes over time. BMC Geriatr., 21(1), 2021, 221.
Moola, S., Munn, Z., Tufanaru, C., Aromataris, E., Sears, K., Sfetcu, R., et al. Chapter 7: systematic reviews of etiology and risk. Aromataris, E., Munn, Z., (eds.) Joanna Brigs Institute Reviewer's Manual, 2020, Joanna Brigs Institute.
E. Aromataris, Z. Munn, Joanna Briggs Institute Reviewers’ Manual: 2020 Edition, Adelaide, SA, 2020.
Page, M.J., Moher, D., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ, 372, 2021, n160.
A.-M. Hanff, C. McCrum, C. Dessenne, C. Pauly, L. Pauly, A.K. Leist, et al., Determinants of patient-reported functional mobility in people with parkinson's disease: protocol for a systematic review of aetiology and risk, Determinants of Patient-reported Functional Mobility in People with Parkinson's Disease: Protocol for A Systematic Review of Aetiology and Risk, OSF Registry: 〈https://osf.io/8ugb7〉, 2022.
World Health Organisation, Towards a Common Language for Functioning, Disability and Health. ICF The International Classification of Functioning, Disability and Health, (2002). 〈https://cdn.who.int/media/docs/default-source/classification/icf/icfbeginnersguide.pdf〉.
Bloem, B.R., Marinus, J., Almeida, Q., Dibble, L., Nieuwboer, A., Post, B., et al. Measurement instruments to assess posture, gait, and balance in Parkinson's disease: critique and recommendations. Mov. Disord. 31:9 (2016), 1342–1355.
Peters, M., Godfrey, C., McInerney, P., Munn, Z., Tricco, A., Khalil, H., Chapter 11: scoping reviews. Aromataris, E., Munn, Z., (eds.) Joanna Briggs Institute Reviewers' Manual, 2020, Joanna Briggs Institute.
Stephenson, M., Riitano, D., Wilson, S., Leonardi-Bee, J., Mabire, C., Cooper, K., et al. Chapter 12: systematic reviews of measurement properties. Aromataris, E., Munn, Z., (eds.) Joanna Briggs Institute Reviewers' Manual, 2020, Joanna Briggs Institute.
Kohl, C., McIntosh, E.J., Unger, S., Haddaway, N.R., Kecke, S., Schiemann, J., et al. Online tools supporting the conduct and reporting of systematic reviews and systematic maps: a case study on CADIMA and review of existing tools. Environ. Evid., 7(1), 2018.
Hong, Q.N., Fàbregues, S., Bartlett, G., Boardman, F., Cargo, M., Dagenais, P., et al. The Mixed Methods Appraisal Tool (MMAT) version 2018 for information professionals and researchers. Educ. Inf. 34:4 (2018), 285–291.
A. Rohatgi, WebPlotDigitizer, WebPlotDigitizer, 〈https://automeris.io/WebPlotDigitizer〉. 2021.
Harrison, E.C., Earhart, G.M., Leventhal, D., Quinn, L., Pietro, M., A walking dance to improve gait speed for people with Parkinson disease: a pilot study. Neurodegener. Dis. Manag 10:5 (2020), 301–308.
Leavy, B., Joseph, C., Löfgren, N., Johansson, H., Hagströmer, M., Franzén, E., Outcome evaluation of highly challenging balance training for people with Parkinson disease: a multicenter effectiveness-implementation study. J. Neurol. Phys. Ther. 44:1 (2020), 15–22.
Olsson, K., Franzén, E., Johansson, A., A pilot study of the feasibility and effects of table tennis training in Parkinson disease. Arch. Rehabil. Res. Clin. Transl., 2(3), 2020, 100064.
Rantakokko, M., Iwarsson, S., Slaug, B., Nilsson, M.H., Life-space mobility in parkinson's disease: associations with motor and non-motor symptoms. J. Gerontol. A Biol. Sci. Med. Sci. 74:4 (2019), 507–512.
Ryder-Burbidge, C., Wieler, M., Nykiforuk, C.I.J., Jones, C.A., Life-space mobility and Parkinson's disease. a multiple-methods study. Mov. Disord. Clin. Pr. 9:3 (2022), 351–361.
Dutra, A.C.L., Soares, N.M., Artigas, N.R., Pereira, G.M., Krimberg, J.S., Ovando, A.C., et al. Life-space mobility, balance, and self-efficacy in Parkinson disease: a cross-sectional study. PM R., 2022.
Daneault, J.-F., Duval, C., Barbat-Artigas, S., Aubertin-Leheudre, M., Jodoin, N., Panisset, M., et al. Subthalamic stimulation improves motor function but not home and neighborhood mobility. Mov. Disord. 29:14 (2014), 1816–1819.
Leavy, B., Lofgren, N., Nilsson, M., Franzen, E., Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease. Brain Behav., 8(9), 2018, e01081.
Nilsson, M.H., Hariz, G.-M., Iwarsson, S., Hagell, P., Walking ability is a major contributor to fear of falling in people with Parkinson's disease: implications for rehabilitation. Park. 'S. Dis., 2012, 1–7 (20420080).
Zajac, J.A., Cavanaugh, J.T., Baker, T., Colón-Semenza, C., DeAngelis, T.R., Duncan, R.P., et al. Are mobile persons with parkinson disease necessarily more active?. J. Neurol. Phys. Ther. 45:4 (2021), 259–265.
Bladh, S., Nilsson, M.H., Hariz, G.M., Westergren, A., Hobart, J., Hagell, P., Psychometric performance of a generic walking scale (Walk-12G) in multiple sclerosis and Parkinson's disease. J. Neurol. 259:4 (2012), 729–738.
Kammerlind, A.S., Fristedt, S., Ernsth Bravell, M., Fransson, E.I., Test-retest reliability of the Swedish version of the Life-Space Assessment Questionnaire among community-dwelling older adults. Clin. Rehabil. 28:8 (2014), 817–823.
Baker, P.S., Bodner, E.V., Allman, R.M., Measuring life-space mobility in community-dwelling older adults. J. Am. Geriatr. Soc. 51:11 (2003), 1610–1614.
Kader, M., Ullen, S., Iwarsson, S., Odin, P., Nilsson, M.H., Factors contributing to perceived walking difficulties in people with Parkinson's disease. J. Park. Dis. 7:2 (2017), 397–407.
World Health Organization, International Classification of Functioning, Disability and Health: ICF, in: d.a.h.I. International Classification of Functioning (Ed.) 2001.
Skorvanek, M., Goldman, J.G., Jahanshahi, M., Marras, C., Rektorova, I., Schmand, B., et al. Global scales for cognitive screening in Parkinson's disease: critique and recommendations. Mov. Disord. 33:2 (2018), 208–218.
Horton, Jr, A.M., Alana, S., Validation of the mini-mental state examination. Int J. Neurosci. 53:2–4 (1990), 209–212.
Hoops, S., Nazem, S., Siderowf, A.D., Duda, J.E., Xie, S.X., Stern, M.B., et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 73:21 (2009), 1738–1745.
Ramos, J.B., Duarte, G.S., Bouca-Machado, R., Fabbri, M., Mestre, T.A., Costa, J., et al. The role of architecture and design in the management of Parkinson's disease: a systematic review. J. Park. Dis. 10:4 (2020), 1301–1314.
Pretzer-Aboff, I., Galik, E., Resnick, B., Parkinson's disease: barriers and facilitators to optimizing function. Rehabil. Nurs. 34:2 (2009), 55–63, 83.
Lamont, R.M., Morris, M.E., Woollacott, M.H., Brauer, S.G., Community walking in people with Parkinson's disease. Park. Dis., 2012, 2012, 856237.
Slaug, B., Nilsson, M.H., Iwarsson, S., Characteristics of the personal and environmental components of person-environment fit in very old age: a comparison between people with self-reported Parkinson's disease and matched controls. Aging Clin. Exp. Res 25:6 (2013), 667–675.
Vandenbroucke, J.P., von Elm, E., Altman, D.G., Gotzsche, P.C., Mulrow, C.D., Pocock, S.J., et al. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Med., 4(10), 2007, e297.
International Committee of Medical Journal Editors. Uniform requirements for manuscripts submitted to biomedical journals: writing and editing for biomedical publication. J. Pharmacol. Pharmacother. 1:1 (2010), 42–58.
Gargon, E., Williamson, P.R., Altman, D.G., Blazeby, J.M., Tunis, S., Clarke, M., The COMET Initiative database: progress and activities update (2015). Trials, 18(1), 2017, 54.
Hanff, A.-M., Pauly, C., Pauly, L., Rauschenberger, A., Leist, A., Krüger, R., et al. Determinants of patient-reported functional mobility in people with Parkinson's disease: a systematic review. OSF Prepr., 22(12), 2022, 10.31219/osf.io/gacs7.
