An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research.
Data harmonization; Epidemiology; Health; Integrative data analysis; Life course; Risk factors; Social Sciences (miscellaneous); Health (social science); Health Policy; Public Health, Environmental and Occupational Health
Abstract :
[en] Life course epidemiology seeks to understand the intricate relationships between risk factors and health outcomes across different stages of life to inform prevention and intervention strategies to optimize health throughout the lifespan. However, extant evidence has predominantly been based on separate analyses of data from individual birth cohorts or panel studies, which may not be sufficient to unravel the complex interplay of risk and health across different contexts. We highlight the importance of a multi-study perspective that enables researchers to: (a) Compare and contrast findings from different contexts and populations, which can help identify generalizable patterns and context-specific factors; (b) Examine the robustness of associations and the potential for effect modification by factors such as age, sex, and socioeconomic status; and (c) Improve statistical power and precision by pooling data from multiple studies, thereby allowing for the investigation of rare exposures and outcomes. This integrative framework combines the advantages of multi-study data with a life course perspective to guide research in understanding life course risk and resilience on adult health outcomes by: (a) Encouraging the use of harmonized measures across studies to facilitate comparisons and synthesis of findings; (b) Promoting the adoption of advanced analytical techniques that can accommodate the complexities of multi-study, longitudinal data; and (c) Fostering collaboration between researchers, data repositories, and funding agencies to support the integration of longitudinal data from diverse sources. An integrative approach can help inform the development of individualized risk scores and personalized interventions to promote health and well-being at various life stages.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Zuber, Sascha; Institute On Aging & Lifelong Health, University of Victoria, Victoria, BC Canada ; Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Geneva, Switzerland
Bechtiger, Laura; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland
Bodelet, Julien Stéphane; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland
Golin, Marta; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland
Heumann, Jens; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland
KIM, Jung Hyun ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
KLEE, Matthias ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC) > Socio-Economic Inequality
MUR, Jure ; University of Luxembourg ; University of Edinburgh, Edinburgh, Scotland
Noll, Jennie; Pennsylvania State University, State College, PA USA
Voll, Stacey; Institute On Aging & Lifelong Health, University of Victoria, Victoria, BC Canada
O'Keefe, Patrick; Department of Neurology, Oregon Health & Science University, Portland, OR USA
Steinhoff, Annekatrin; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland ; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland
Zölitz, Ulf; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland
Muniz-Terrera, Graciela; Ohio University, Athens, OH USA
Shanahan, Lilly; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland ; Department of Psychology, University of Zürich, Zürich, Switzerland
Shanahan, Michael J; Jacobs Center for Productive Youth Development, University of Zürich, Zürich, Switzerland ; Department of Sociology, University of Zürich, Zürich, Switzerland
Hofer, Scott M; Institute On Aging & Lifelong Health, University of Victoria, Victoria, BC Canada ; Department of Neurology, Oregon Health & Science University, Portland, OR USA
An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research.
Jacobs Center for Productive Youth Development Jacobs Foundation Harald Mohr, M.D. and Wilhelma Mohr, M.D. Research Chair in Adult Development and Aging, University of Victoria Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung National Institute on Aging of the National Institutes of Health
Funding text :
This research was supported by a Small Interdisciplinary Research Fund (SMIRF) from the Jacobs Center for Productive Youth Development, the Jacobs Foundation and research funds from the Harald Mohr, M.D. and Wilhelma Mohr, M.D. Research Chair in Adult Development and Aging, University of Victoria. Sascha Zuber acknowledges funding from the Swiss National Science Foundation (SNSF; Grant Number: P400PS_199283). Scott Hofer, Graciela Muniz, and Patrick O’Keefe were also supported by the National Institute on Aging of the National Institutes of Health under award number 1R01AG067621.
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