Drugs from hidden bugs: their discovery via untapped resources.

Lefevre, Fabrice; Robe, Patrick; Jarrin, Cyrille; GINOLHAC, Aurélien; Zago, Caroline; Auriol, Daniel; Vogel, Timothy M; Simonet, Pascal; Nalin, Renaud

doi:10.1016/j.resmic.2007.12.011

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Drugs from hidden bugs: their discovery via untapped resources.

Lefevre, Fabrice; Robe, Patrick; Jarrin, Cyrille et al.

2008 • In Research in Microbiology, 159 (3), p. 153-61

Peer Reviewed verified by ORBi

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https://hdl.handle.net/10993/58148

DOI
10.1016/j.resmic.2007.12.011

PubMed
18375103

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Keywords :

Biological Factors; DNA, Bacterial; Bacteria/classification/genetics/metabolism; Biological Factors/genetics/isolation & purification/metabolism/pharmacology; DNA, Bacterial/genetics/metabolism; Drug Evaluation, Preclinical/methods; Genomic Library; Phylogeny; Soil Microbiology

Abstract :

[en] The drug discovery process is a starving machine requiring constant feeding with new chemical compounds. Synthetic or natural scaffolds: what are the best sources? While synthetic molecules are rapidly generated by combinatorial chemistry, they show lower chemical diversity than their natural counterparts. A significant fraction of known natural products is issued from microbial secondary metabolism; however, more than 95% of bacterial organisms remain unexploited as a source of active chemical compounds due to their cultivation difficulties. Recent technological advances in metagenomics have provided reliable access to chemicals of these hidden bugs, thus opening up new opportunities for feeding the machine.

Disciplines :

Biotechnology

Author, co-author :

Lefevre, Fabrice; LibraGen, 3 rue des Satellites, Bâtiment Canal Biotech I, 31400 Toulouse, France. f.lefevre@libragen.com

Robe, Patrick

Jarrin, Cyrille

GINOLHAC, Aurélien

Zago, Caroline

Auriol, Daniel

Vogel, Timothy M

Simonet, Pascal

Nalin, Renaud

External co-authors :

Language :

English

Title :

Drugs from hidden bugs: their discovery via untapped resources.

Publication date :

April 2008

Journal title :

Research in Microbiology

ISSN :

0923-2508

eISSN :

1769-7123

Publisher :

Elsevier, Nl

Volume :

159

Issue :

Pages :

153-61

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 29 November 2023

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