Long-COVID; COVID-19; persistent COVID-19 symptoms; post-COVID-19 syndrome; mental health
Abstract :
[en] IntroductionChronic post-viral syndromes, including Long-COVID, are characterized by a range of persistent symptoms that occur following a viral infection. Psychological symptoms are prevalent in Long-COVID patients and can have a significant impact on their quality of life. However, the specific patterns of psychological symptoms, their associations with physical symptoms, and the factors predicting their severity remain poorly understood.AimsThis study aims to explore and systematically assess psychological symptoms in Long-COVID, to identify syndrome clusters based on these symptoms, to examine their relationship with physical symptoms, and to investigate the influence of pandemic-related variables.MethodsDescriptive, cross-sectional study with data collected through an online questionnaire across several EU countries, from February 2020 to December 2022. Participants were recruited using public relations, the social media and information campaigns directed at the public and health professionals using snowball sampling.ResultsThe findings will allow to phenotype Long-COVID related psychological symptom clusters based on self-reports. facilitating improved assessment and treatment approaches.ConclusionsThe results will provide important knowledge for the public health management of the public healh management of Long COVID. The findings will contribute to a better understanding of the psychological symptoms associated with Long-COVID and the development of specific treatment guidelines for psychological burden associated with Long-COVID, thereby supporting management strategies to combat the after-effects of the COVID-19 pandemic, enhancing their overall well-being and quality of life.
Disciplines :
Social & behavioral sciences, psychology: Multidisciplinary, general & others
Author, co-author :
Gómez Bravo, Raquel; Centre Hospitalier Neuropsychiatrique (CHNP) > Rehaklinik > Luxembourg ; Department of Behavioural and Cognitive Sciences > Faculty of Humanities, Education, and Social Sciences > University of Luxembourg, Esch-sur-Alzette, Luxembourg
INFANTI, Alexandre ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) > Health and Behaviour
Billieux, Joël; Institute of Psychology > University of Lausanne (UNIL) > Switzerland
Ritzen, Mark; Centre Hospitalier Neuropsychiatrique (CHNP) > Rehaklinik > Luxembourg
Vögele, Claus; Department of Behavioural and Cognitive Sciences > Faculty of Humanities, Education, and Social Sciences > University of Luxembourg, Esch-sur-Alzette, Luxembourg
Benoy, Charles; Centre Hospitalier Neuropsychiatrique (CHNP) > Rehaklinik > Luxembourg ; Universitäre Psychiatrische Kliniken Base > Zentrum für Psychosomatik und Psychotherapie > Basel, Switzerland ; Department of Clinical Research > University of Basel > Basel, Switzerland
External co-authors :
yes
Language :
English
Title :
The psychological syndrome associated with Long-COVID: A study protocol
Moldofsky H Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol. (2011) 11(1):1–7. 10.1186/1471-2377-11-3721208452
Davis HE McCorkell L Vogel JM Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. (2023) 21(3):133–46. 10.1038/s41579-022-00846-236639608
Raveendran AV Jayadevan R Sashidharan S. Long COVID: an overview. Diabetes Metab Syndr. (2021) 15(3):869–75. 10.1016/j.dsx.2021.04.00733892403
Havervall S Rosell A Phillipson M Mangsbo SM Nilsson P Hober S et al. Symptoms and functional impairment assessed 8 months after mild COVID-19 among health care workers. J Am Med Assoc. (2021) 325(19):2015–6. 10.1001/jama.2021.5612
Ceban F Ling S Lui LMW Lee Y Gill H Teopiz KM et al. Fatigue and cognitive impairment in post-COVID-19 syndrome: a systematic review and meta-analysis. Brain Behav Immun. (2022) 101:93–135. 10.1016/j.bbi.2021.12.02034973396
Gold JE Okyay RA Licht WE Hurley DJ. Investigation of long COVID prevalence and its relationship to epstein-barr virus reactivation. Pathogens. (2021) 10(6):763. 10.3390/pathogens1006076334204243
Logue JK Franko NM McCulloch DJ McDonald D Magedson A Wolf CR et al. Sequelae in adults at 6 months after COVID-19 infection. JAMA Netw Open. (2021) 4(2):e210830. 10.1001/jamanetworkopen.2021.083033606031
Sudre CH Murray B Varsavsky T Graham MS Penfold RS Bowyer RC et al. Attributes and predictors of long COVID. Nat Med. (2021) 27(4):626–31. 10.1038/s41591-021-01292-y33692530
Nguyen NN Hoang VT Dao TL Dudouet P Eldin C Gautret P. Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review. Eur J Clin Microbiol Infect Dis. (2022) 41(4):515–45. 10.1007/s10096-022-04417-435142947
Iqbal FM Lam K Sounderajah V Clarke JM Ashrafian H Darzi A. Characteristics and predictors of acute and chronic post-COVID syndrome: a systematic review and meta-analysis. EClinicalMedicine. (2021) 36:100899. 10.1016/j.eclinm.2021.10089934036253
Salari N Khodayari Y Hosseinian-Far A Zarei H Rasoulpoor S Akbari H et al. Global prevalence of chronic fatigue syndrome among long COVID-19 patients: a systematic review and meta-analysis. BioPsychoSoc Med. (2022) 16(1):21. 10.1186/s13030-022-00250-536274177
Orrù G Bertelloni D Diolaiuti F Mucci F Di Giuseppe M Biella M et al. Long-COVID syndrome? A study on the persistence of neurological, psychological and physiological symptoms. Healthcare. (2021) 9(5):575. 10.3390/healthcare9050575
Patel UK Mehta N Patel A Patel N Ortiz JF Khurana M et al. Long-term neurological sequelae among severe COVID-19 patients: a systematic review and meta-analysis. Cureus. (2022) 14(9):e29694. 10.7759/cureus.2969436321004
Townsend L Dyer AH Jones K Dunne J Mooney A Gaffney F et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. Plos One. (2020) 15(11):e0240784. 10.1371/journal.pone.024078433166287
Taquet M Dercon Q Luciano S Geddes JR Husain M Harrison PJ. Incidence, co-occurrence, and evolution of long-COVID features: a 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Med. (2021) 18(9):e1003773. 10.1371/journal.pmed.100377334582441
Komaroff AL Bateman L. Will COVID-19 lead to myalgic encephalomyelitis/chronic fatigue syndrome? Front Med. (2021) 7:1132. 10.3389/fmed.2020.606824
Wong TL Weitzer DJ. Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a systemic review and comparison of clinical presentation and symptomatology. Medicina. (2021) 57(5):418. 10.3390/medicina5705041833925784
Efstathiou V Stefanou MI Demetriou M Siafakas N Makris M Tsivgoulis G et al. Long COVID and neuropsychiatric manifestations (review). Exp Ther Med. (2022) 23(5):363. 10.3892/etm.2022.1129035493431
Gemelli Against COVID-19 Post-Acute Care Study Group. Post-COVID-19 global health strategies: the need for an interdisciplinary approach. Aging Clin Exp Res. (2020) 32:1613–1620. 10.1007/s40520-020-01616-x32529595
Prince M Patel V Saxena S Maj M Maselko J Phillips MR et al. No health without mental health. Lancet. (2007) 370:859–77. 10.1016/S0140-6736(07)61238-017804063
Evans DL Charney DS Lewis L Golden RN Gorman JM Krishnan KR et al. Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry. (2005) 58:175–89. 10.1016/j.biopsych.2005.05.00116084838
WHO. Post COVID-19 condition (long COVID) (2022). Available at: https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition#:∼:text=It%20is%20defined%20as%20the,months%20with%20no%20other%20explanation.
Hair JF Black WC Babin BJ Anderson RE. Multivariate data analysis. A global perspective. 7th ed. Upper Saddle River (N.J.): Pearson education (2010).
Charrad M Ghazzali N Boiteau V Niknafs A. Nbclust: an R package for determining the relevant number of clusters in a data set. J Stat Softw. (2014) 61(6):1–36. 10.18637/jss.v061.i06
Ebbert D. chisq.posthoc.test: a post hoc analysis for Pearson’s chi-squared test for count data. R package version 0.1.2 (2019). Available at: https://CRAN.R-project.org/package=chisq.posthoc.test.
Ballering AV van Zon SKR Olde Hartman TC Rosmalen JGM, Lifelines Corona Research Initiative. Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study. Lancet. (2022) 400(10350):452–61. 10.1016/S0140-6736(22)01214-435934007
Nehme M Chappuis F Kaiser L Assal F Guessous I. The prevalence, severity, and impact of post-COVID persistent fatigue, post-exertional malaise, and chronic fatigue syndrome. J Gen Intern Med. (2023) 38:835–9. 10.1007/s11606-022-07882-x36357723