cancer; immunity; immunometabolism; immunotherapy; metabolism; obesity; Humans; Immune System; Metabolic Networks and Pathways; Obesity/therapy; Obesity/metabolism; Tumor Microenvironment; Neoplasms/metabolism; Neoplasms; Neuroscience (all); Biochemistry, Genetics and Molecular Biology (all); History and Philosophy of Science; General Biochemistry, Genetics and Molecular Biology; General Neuroscience
Abstract :
[en] Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.
Disciplines :
Immunology & infectious disease
Author, co-author :
Cable, Jennifer; PhD Science Writer, New York, New York, USA
Rathmell, Jeffrey C; Vanderbilt-Ingram Cancer Center, Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Pearce, Erika L; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA ; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
Ho, Ping-Chih; Department of Fundamental Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland
Haigis, Marcia C; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA
Mamedov, Murad R; Gladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California, USA
Wu, Meng-Ju; Cancer Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Kaech, Susan M; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA
Lynch, Lydia; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Febbraio, Mark A; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
Bapat, Sagar P; Diabetes Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA
Hong, Hanna S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
Zou, Weiping; Department of Surgery, Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Department of Pathology, Graduate Program in Immunology, Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Belkaid, Yasmine; Metaorganism Immunity Section, Laboratory of Immune System Biology, and NIAID Microbiome Program National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Sullivan, Zuri A; Department of Immunobiology, Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
Keller, Andrea; Department of Biological Chemistry and Pharmacology, College of Medicine, and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio, USA
Wculek, Stefanie K; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
Green, Douglas R; St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Postic, Catherine; Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France
Amit, Ido; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
Benitah, Salvador Aznar; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
Jones, Russell G; Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan, USA
Reina-Campos, Miguel; University of California, San Diego, La Jolla, California, USA
Torres, Santiago Valle; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia
Beyaz, Semir; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
Brennan, Donal; UCD Gynecological Oncology Group, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Belfield, Ireland
O'Neill, Luke A J; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland
Perry, Rachel J; Department of Cellular and Molecular Physiology and Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA
BRENNER, Dirk ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Immunology and Genetics ; Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark
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