[en] One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.
Disciplines :
Immunology & infectious disease
Author, co-author :
Kurniawan, Henry; Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg, Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg
Kobayashi, Takumi ; Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg, Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg
BRENNER, Dirk ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Immunology and Genetics
External co-authors :
no
Language :
English
Title :
The emerging role of one-carbon metabolism in T cells.
We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. D.B. and H.K. are supported by the FNR-ATTRACT program ( A14/BM/7632103 ), and D.B. by the FNR-CORE ( C18/BM/12691266 ) and the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme. The figures are created using Biorender.com.
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