[en] Regulatory T cells (Tregs) are critical for peripheral immune tolerance and homeostasis, and altered Treg behavior is involved in many pathologies, including autoimmunity and cancer. The expression of the transcription factor FoxP3 in Tregs is fundamental to maintaining their stability and immunosuppressive function. Recent studies have highlighted the crucial role that metabolic reprogramming plays in controlling Treg plasticity, stability, and function. In this review, we summarize how the availability and use of various nutrients and metabolites influence Treg metabolic pathways and activity. We also discuss how Treg-intrinsic metabolic programs define and shape their differentiation, FoxP3 expression, and suppressive capacity. Lastly, we explore how manipulating the regulation of Treg metabolism might be exploited in different disease settings to achieve novel immunotherapies.
Disciplines :
Oncology
Author, co-author :
Kurniawan, Henry; Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg
Soriano-Baguet, Leticia; Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg ; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
BRENNER, Dirk ; University of Luxembourg ; Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark
External co-authors :
no
Language :
English
Title :
Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer.
We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. The figures were created using Biorender.com. D.B. and H.K. are supported by the FNR-ATTRACT program (A14/BM/7632103) and D.B. by FNR-CORE (C18/BM/12691266). D.B. and L.S.B. are funded by the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme.We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. The figures were created using Biorender.com. D.B. and H.K. are supported by the FNR‐ATTRACT program (A14/BM/7632103) and D.B. by FNR‐CORE (C18/BM/12691266). D.B. and L.S.B. are funded by the FNR‐PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme.
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