ROS; T cell; antioxidants; glutathione; metabolic reprogramming; Reactive Oxygen Species; Adenosine Triphosphate; Adenosine Triphosphate/metabolism; Animals; Glycolysis; Humans; Mitochondria/metabolism; Models, Biological; Reactive Oxygen Species/metabolism; T-Lymphocytes/metabolism; Energy Metabolism; Signal Transduction; Mitochondria; T-Lymphocytes; Immunology and Allergy; Immunology
Résumé :
[en] T cells are a central component of defenses against pathogens and tumors. Their effector functions are sustained by specific metabolic changes that occur upon activation, and these have been the focus of renewed interest. Energy production inevitably generates unwanted products, namely reactive oxygen species (ROS), which have long been known to trigger cell death. However, there is now evidence that ROS also act as intracellular signaling molecules both in steady-state and upon antigen recognition. The levels and localization of ROS contribute to the redox modeling of effector proteins and transcription factors, influencing the outcome of the T cell response. We discuss here how ROS can directly fine-tune metabolism and effector functions of T cells.
Disciplines :
Immunologie & maladie infectieuse
Auteur, co-auteur :
Franchina, Davide G; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg
Dostert, Catherine; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg
BRENNER, Dirk ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Immunology and Genetics ; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg, Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Electronic address: dirk.brenner@lih.lu
Co-auteurs externes :
no
Langue du document :
Anglais
Titre :
Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism.
We thank the Luxembourg National Research Fund (FNR) for support. D.B. is funded through the FNR-ATTRACT program and a FNR-CORE grant ( C15/BM/10355103 ). D.B. and D.G.F. are supported through the FNR-RIKEN and FNR-PRIDE funding schemes.We thank the Luxembourg National Research Fund (FNR) for support. D.B. is funded through the FNR-ATTRACT program (A14/BM/7632103) and the FNR-CORE (C15/BM/10355103) and the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) funding schemes. D.B. and D.G.F. are supported through the FNR-RIKEN (TregBar/11228353) grant.
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