B cell; HIF-1α; Myc; immunometabolism; lymphoma; Animals; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Energy Metabolism; Humans; Neoplasms/immunology; Neoplasms/metabolism; Neoplasms/therapy; B-Lymphocytes; Neoplasms; Oncology; Cancer Research
Abstract :
[en] Cells of the immune system display varying metabolic profiles to fulfill their functions. B lymphocytes overcome fluctuating energy challenges as they transition from the resting state and recirculation to activation, rapid proliferation, and massive antibody production. Only through a controlled interplay between metabolism, extracellular stimuli, and intracellular signaling can successful humoral responses be mounted. Alterations to this balance can promote malignant transformation of B cells. The metabolic control of B-cell fate is only partially understood. Here, we provide a compelling overview of the current state of the art and describe the main metabolic features of B cells during normal development and oncogenesis, with emphasis on the major B-cell transcriptional and metabolic regulators, including myelocytomatosis virus oncogene cellular homolog (Myc) and hypoxia-inducible factor 1-α (HIF-1α).
Disciplines :
Immunology & infectious disease
Author, co-author :
Franchina, Davide G; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg
Grusdat, Melanie; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg
BRENNER, Dirk ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Immunology and Genetics ; Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-sur-Alzette, Luxembourg, Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Electronic address: dirk.brenner@lih.lu
We thank the Luxembourg National Research Fund (FNR) for support: D.B. is funded through the FNR-ATTRACT program and an FNR-CORE grant (C15/BM/10355103). In addition, D.B. and D.G.F. are supported through the FNR-RIKEN and FNR-PRIDE funding schemes.We thank the Luxembourg National Research Fund (FNR) for support: D.B. is funded through the FNR-ATTRACT program and an FNR-CORE grant ( C15/BM/10355103 ). In addition, D.B. and D.G.F. are supported through the FNR-RIKEN and FNR-PRIDE funding schemes.
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