DNA; NAD; T cells; acetylation; epigentics; histone; metabolism
Résumé :
[en] T cell subsets adapt and rewire their metabolism according to their functions and surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic pathways characterized by low nutrient requirements, effector T cells induce kinetically faster pathways to generate the biomass and energy needed for proliferation and cytokine production. Recent findings support the concept that alterations in metabolism also affect the epigenetics of T cells. In this review we discuss the connections between T cell metabolism and epigenetic changes such as histone post-translational modifications (PTMs) and DNA methylation, as well as the 'extra-metabolic' roles of metabolic enzymes and molecules. These findings collectively point to a new group of potential therapeutic targets for the treatment of T cell-dependent autoimmune diseases and cancers.
Disciplines :
Immunologie & maladie infectieuse
Auteur, co-auteur :
Soriano-Baguet, Leticia ; Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg, Immunology and Genetics, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
BRENNER, Dirk ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Immunology and Genetics
Co-auteurs externes :
no
Langue du document :
Anglais
Titre :
Metabolism and epigenetics at the heart of T cell function.
FNR; PRIDE/11012546/NEXTIMMUNE,; FNR CORE Grants C21/BM/15796788 and C18/BM/12691266
Subventionnement (détails) :
We apologize to researchers whose work could not be referenced here owing to space limitations. We thank Anouk Ewen for the design of the figures using BioRender.com . L.S-B. and D.B. are supported by the Fonds National de la Recherche Luxembourg ( FNR ; PRIDE/11012546/NEXTIMMUNE). D.B. is supported by FNR CORE grants ( C21/BM/15796788 and C18/BM/12691266 ).
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