Reference : Epithelial factors: modulation of the airway smooth muscle tone
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Epithelial factors: modulation of the airway smooth muscle tone
Bertrand, C. [> >]
Tschirhart, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Fundamental and Clinical Pharmacology
Blackwell Science
Yes (verified by ORBilu)
United Kingdom
[en] Animals ; physiology ; Trachea ; Muscle, Smooth ; Muscle Tonus ; Muscle Contraction ; Humans ; Epithelium ; Bronchi ; Biological Factors ; secretion
[en] The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also metabolize some of the inflammatory mediators. Epithelial damage is a consistent feature of some respiratory conditions, but whether or not such damage contributes to airway disease is for the moment unknown. This review summarizes the literature on the known and proposed roles of the epithelium in the modulation of the airway smooth muscle tone.

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