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An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea
Bertrand, C.; Da Silva, A.; Landry, Y. et al.
1993In Pulmonary Pharmacology, 6 (1), p. 69-76
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Keywords :
Acetylcholine; physiology; pharmacology; Trachea; Tetrodotoxin; Synaptic Transmission; Potassium; Neurokinin A; Muscle, Smooth; Muscle Contraction; Male; Guinea Pigs; Epithelium; Calcium Chloride; Calcium; Calcitonin Gene-Related Peptide; Calcimycin; Animals; drug effects
Abstract :
[en] The effects of epithelium removal were studied on the contraction induced by Ca2+ in K(+)-depolarizing solution, and by the calcium ionophore A 23187 in guinea-pig isolated tracheal strips. Epithelium removal reduced the maximal response to Ca2+ in K(+)-depolarizing solution and caused a significant shift to the right of the Ca2+ concentration-response curves. The contraction induced by the calcium ionophore A 23187 (10(-6) M) was also markedly reduced by epithelium removal. These results suggest the occurrence of an epithelium-derived contracting factor. The effects of hexamethonium, atropine, spantide and thiorphan showed that acetylcholine and neurokinins play a minor role in the Ca(2+)-induced contraction. The epithelium-dependent potentiation of the calcium- and of the A 23187-induced contractions was inhibited by an antibody selective for rat calcitonin gene-related peptide (rCGRP alpha). Therefore, CGRP-like immunoreactive material may be part of the epithelium-dependent contracting factor of guinea-pig trachea. Comparison of concentration-response curves for rCGRP alpha in epithelium-free and in intact guinea-pig tracheal strips suggests that an epithelium-dependent contracting factor may be mobilized by CGRP.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
Author, co-author :
Bertrand, C.
Da Silva, A.
Landry, Y.
Theodorsson, E.
TSCHIRHART, Eric ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
Title :
An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea
Publication date :
Journal title :
Pulmonary Pharmacology
Publisher :
Academic Press, London, United Kingdom
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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since 09 September 2013


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