Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review.

Curcumin; NLRP3 inflammasome; Phytochemical; Resveratrol; Sulforaphane; Inflammasomes; Isothiocyanates; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3 protein, human; Phytochemicals; Sulfoxides; sulforaphane; Animals; Cardiovascular Diseases/drug therapy; Cardiovascular Diseases/metabolism; Central Nervous System Diseases/drug therapy; Central Nervous System Diseases/metabolism; Curcumin/pharmacology; Humans; Inflammasomes/antagonists & inhibitors; Inflammasomes/drug effects; Inflammasomes/metabolism; Inflammation/drug therapy; Inflammation/metabolism; Isothiocyanates/pharmacology; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Phytochemicals/therapeutic use; Resveratrol/pharmacology; Signal Transduction/drug effects; Cardiovascular Diseases; Central Nervous System Diseases; Inflammation; Signal Transduction; Molecular Medicine; Pharmacology; Pharmaceutical Science; Drug Discovery; Complementary and Alternative Medicine

Abstract :

[en] [en] BACKGROUND: The NLRP3 inflammasome formation and following cytokine secretion is a crucial step in innate immune responses. Internal and external factors may trigger inflammasome activation and result in inflammatory cytokine secretion. Inflammasome formation and activity play critical roles in several disease pathologies such as cardiovascular, metabolic, renal, digestive, and CNS diseases. Underlying pathways are not yet clear, but phytochemicals as alternative therapies have been extensively used for suppression of inflammatory responses. PURPOSE: In this review, we aimed to summarize in vivo and in vitro effects on NLRP3 inflammasome activation of selected phytochemicals. METHOD: Three phytochemicals; Sulforaphane, Curcumin, and Resveratrol were selected, and studies were reviewed to clarify their intracellular signaling mechanism in NLRP3 inflammasome activity. PubMed and Scopus databases are used for the search. For sulforaphane, 8 articles, for curcumin, 25 articles, and for resveratrol, 41 articles were included in the review. CONCLUSION: In vitro and in vivo studies pointed out that the selected phytochemicals have inhibitory properties on NLRP3 inflammasome activity. However, neither the mechanism is clear, nor the study designs and doses are standardized.

Precision for document type :

Review article

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Olcum, Melis ^✱; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey

TASTAN, Bora ^✱; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Neuroinflammation Group ; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey

Ercan, Ilkcan; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey

Eltutan, Irem B; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey

Genc, Sermin ; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey, Department of Neuroscience, Health Science Institute, Dokuz Eylul University, Izmir, Turkey. Electronic address: sermin.genc@deu.edu.tr

^✱ These authors have contributed equally to this work.

External co-authors :

yes

Language :

English

Title :

Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review.

Publication date :

15 August 2020

Journal title :

Phytomedicine

ISSN :

0944-7113

eISSN :

1618-095X

Publisher :

Elsevier GmbH, Germany

Volume :

Pages :

153238

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0944711320300696?httpAccept=text/xml

Available on ORBilu :

since 05 October 2023

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