[en] Exosomes, a type of extracellular vesicle, are small vesicles (30-100 nm) secreted into extracellular space from almost all types of cells. Exosomes mediate cell-to-cell communication carrying various biologically active molecules including microRNAs. Studies have shown that exosomal microRNAs play fundamental roles in healthy and pathological conditions such as immunity, cancer, and inflammation. In this chapter, we introduce the current knowledge on exosome biogenesis, techniques used in exosome research, and exosomal miRNA and their functions in biological and pathological processes.
Precision for document type :
Review article
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
TASTAN, Bora ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Neuroinflammation Group ; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey
Tarakcioglu, Emre; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey
Birinci, Yelda; Department of Molecular Biology and Genetics, Science Faculty, Koç University, Istanbul, Turkey
Park, Yongsoo; Department of Molecular Biology and Genetics, Science Faculty, Koç University, Istanbul, Turkey
Genc, Sermin; Department of Neuroscience, Institute of Health Science, University of Dokuz Eylul, Izmir, Turkey. sermin.genc@deu.edu.tr ; Izmir Biomedicine and Genome Center, Izmir, Turkey. sermin.genc@deu.edu.tr
External co-authors :
yes
Language :
English
Title :
Role of Exosomal MicroRNAs in Cell-to-Cell Communication.
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