NLRP3 inflammasome; Nrf2; central nervous system; dimethyl fumarate; inflammation; sulforaphane; Inflammasomes; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Humans; Inflammation/metabolism; NF-E2-Related Factor 2/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Central Nervous System Diseases; Inflammasomes/metabolism; GA-Binding Protein Transcription Factor; Immunology and Allergy; Immunology
Résumé :
[en] The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential role in the innate immune system by identifying and eliminating a plethora of endogenous and exogenous threats to the host. Upon activation of the NLRP3 complex, pro-inflammatory cytokines are processed and released. Furthermore, activation of the NLRP3 inflammasome complex can induce pyroptotic cell death, thereby propagating the inflammatory response. The aberrant activity and detrimental effects of NLRP3 inflammasome activation have been associated with cardiovascular, neurodegenerative, metabolic, and inflammatory diseases. Therefore, clinical strategies targeting the inhibition of the self-propelled NLRP3 inflammasome activation are required. The transcription factor Nrf2 regulates cellular stress response, controlling the redox equilibrium, metabolic programming, and inflammation. The Nrf2 pathway participates in anti-oxidative, cytoprotective, and anti-inflammatory activities. This prominent regulator, through pharmacologic activation, could provide a therapeutic strategy for the diseases to the etiology and pathogenesis of which NLRP3 inflammasome contributes. In this review, current knowledge on NLRP3 inflammasome activation and Nrf2 pathways is presented; the relationship between NLRP3 inflammasome signaling and Nrf2 pathway, as well as the pre/clinical use of Nrf2 activators against NLRP3 inflammasome activation in disorders of the central nervous system, are thoroughly described. Cumulative evidence points out therapeutic use of Nrf2 activators against NLRP3 inflammasome activation or diseases that NLRP3 inflammasome contributes to would be advantageous to prevent inflammatory conditions; however, the side effects of these molecules should be kept in mind before applying them to clinical practice.
Précision sur le type de document :
Compte rendu
Disciplines :
Biochimie, biophysique & biologie moléculaire
Auteur, co-auteur :
TASTAN, Bora ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Neuroinflammation Group ; Genc Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey ; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey
Arioz, Burak I; Genc Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey ; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey
Genc, Sermin; Genc Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey ; Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders.
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