Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches.

Animals; Humans; Alzheimer Disease/metabolism; Mitophagy/physiology; Autophagy/genetics; Mitochondria/metabolism; Disease Models, Animal; Amyloid beta-Peptides/metabolism

Résumé :

[en] Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments in mitophagy, the process of selective mitochondrial degradation by autophagy leading to a gradual accumulation of defective mitochondria, have also been reported to occur in AD. We provide an updated overview of the recent discoveries and advancements on mitophagic molecular dysfunctions in AD-derived fluids and cells as well as in AD brains. We discuss studies using AD cellular and animal models that have unraveled the contribution of relevant AD-related proteins (Tau, Aβ, APP-derived fragments and APOE) in mitophagy failure. In accordance with the important role of impaired mitophagy in AD, we report on various therapeutic strategies aiming at stimulating mitophagy in AD and we summarize the benefits of these potential therapeutic strategies in human clinical trials.

Disciplines :

Biochimie, biophysique & biologie moléculaire

Auteur, co-auteur :

MARY, Arnaud ; Université Côte d'Azur, INSERM, CNRS, IPMC, France, Laboratory of excellence DistALZ, 660 route des Lucioles,6560, Sophia-Antipolis, Valbonne, France.

Eysert, Fanny

Checler, Frédéric

Chami, Mounia

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches.

Date de publication/diffusion :

2023

Titre du périodique :

Molecular Psychiatry

ISSN :

1359-4184

eISSN :

1476-5578

Maison d'édition :

Nature Publishing Group, Royaume-Uni

Volume/Tome :

Fascicule/Saison :

Pagination :

202-216

Peer reviewed :

Peer reviewed vérifié par ORBi

Commentaire :

Disponible sur ORBilu :

depuis le 12 septembre 2023

Statistiques

Nombre de vues

127 (dont 10 Unilu)

Nombre de téléchargements

64 (dont 2 Unilu)

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citations Scopus^®

171

citations Scopus^®
sans auto-citations

169

citations OpenAlex

191

citations WoS^™

161

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