[en] INTRODUCTION: Functional mobility is an important outcome for people with Parkinson's disease (PwP). Despite this, there is no established patient-reported outcome measure that serves as a gold standard for assessing patient-reported functional mobility in PwP. We aimed to validate the algorithm calculating the Parkinson's Disease Questionnaire-39 (PDQ-39) based Functional Mobility Composite Score (FMCS). METHODS: We designed a count-based algorithm to measure patient-reported functional mobility in PwP from items of the PDQ-39 subscales mobility and activities of daily living. Convergent validity of the algorithm calculating the PDQ-39-based FMCS was assessed using the objective Timed Up and Go (n = 253) and discriminative validity was assessed by comparing the FMCS with patient-reported (MDS-UPDRS II) and clinician-assessed (MDS-UPDRS III) motor symptoms as well as between disease stages (H&Y) and PIGD phenotypes (n = 736). Participants were between 22 and 92 years old, with a disease duration from 0 to 32 years and 64.9% in a H&Y 1-2 ranging from 1 to 5. RESULTS: Spearman correlation coefficients (r(s)) ranging from -0.45 to -0.77 (p < 0.001) indicated convergent validity. Hence, a t-test suggested sufficient ability of the FMCS to discriminate (p < 0.001) between patient-reported and clinician-assessed motor symptoms. More specifically, FMCS was more strongly associated with patient-reported MDS-UPDRS II (r(s) = -0.77) than clinician-reported MDS-UPDRS III (r(s) = -0.45) and can discriminate between disease stages as between PIGD phenotypes (p < 0.001). CONCLUSION: The FMCS is a valid composite score to assess functional mobility through patient reports in PwP for studying functional mobility in studies using the PDQ-39.
Disciplines :
Neurologie
Auteur, co-auteur :
HANFF, Anne-Marie ; University of Luxembourg > Faculty of Science, Technology and Medecine (FSTM)
McCrum, Christopher
RAUSCHENBERGER, Armin ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science
Aguayo, Gloria A.
Zeegers, Maurice P.
LEIST, Anja ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC)
KRÜGER, Rejko ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Validation of a Parkinson's disease questionnaire-39-based functional mobility composite score (FMCS) in people with Parkinson's disease.
Goetz, C.G., Poewe, W., Rascol, O., Sampaio, C., Stebbins, G.T., Counsell, C., Giladi, N., Holloway, R.G., Moore, C.G., Wenning, G.K., Yahr, M.D., Seidl, L., Movement disorder society task force on rating scales for Parkinson's, movement disorder society task force report on the Hoehn and Yahr staging scale: status and recommendations. Mov. Disord. 19:9 (2004), 1020–1028 D.
Tosserams, A., de Vries, N.M., Bloem, B.R., Nonnekes, J., Multidisciplinary care to optimize functional mobility in Parkinson disease. Clin. Geriatr. Med. 36:1 (2020), 159–172.
Bouca-Machado, R., Maetzler, W., Ferreira, J.J., What is functional mobility applied to Parkinson's disease?. J. Parkinsons Dis. 8:1 (2018), 121–130.
Lindh-Rengifo, M., Jonasson, S.B., Ullen, S., Mattsson-Carlgren, N., Nilsson, M.H., Perceived walking difficulties in Parkinson's disease - predictors and changes over time. BMC Geriatr., 21(1), 2021, 221.
Mirelman, A., Bonato, P., Camicioli, R., Ellis, T.D., Giladi, N., Hamilton, J.L., Hass, C.J., Hausdorff, J.M., Pelosin, E., Almeida, Q.J., Gait impairments in Parkinson's disease. Lancet Neurol. 18:7 (2019), 697–708.
Shulman, L.M., Gruber-Baldini, A.L., Anderson, K.E., Vaughan, C.G., Reich, S.G., Fishman, P.S., Weiner, W.J., The evolution of disability in Parkinson disease. Mov. Disord. 23:6 (2008), 790–796.
Tan, D.M., Danoudis, M.E., McGinley, J., Morris, M.E., Relationships between motor aspects of gait impairments and activity limitations in people with Parkinson's disease: a systematic review. Parkinsonism Relat. Disorders 18:2 (2012), 117–124.
Tan, D.M., McGinley, J.L., Danoudis, M.E., Iansek, R., Morris, M.E., Freezing of gait and activity limitations in people with Parkinson's disease. Arch. Phys. Med. Rehabil. 92:7 (2011), 1159–1165.
Creaby, M.W., Cole, M.H., Gait characteristics and falls in Parkinson's disease: a systematic review and meta-analysis. Parkinsonism Relat. Disorders 57 (2018), 1–8.
Hammarlund, C.S., Andersson, K., Andersson, M., Nilsson, M.H., Hagell, P., The significance of walking from the perspective of people with Parkinson's disease. J. Parkinsons Dis. 4:4 (2014), 657–663.
Hanff, A.-M., Leist, A.K., Fritz, J.V., Pauly, C., Kruger, R., Halek, M., on behalf of the NCER-PD consortium. Determinants of self-stigma in people with Parkinson's disease: a mixed methods scoping review. J. Parkinsons Dis.(2), 2021, 509–522.
Perez-Lloret, S., Negre-Pages, L., Damier, P., Delval, A., Derkinderen, P., Destee, A., Meissner, W.G., Schelosky, L., Tison, F., Rascol, O., Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease. JAMA Neurol. 71:7 (2014), 884–890.
Bowring, F., Welch, J., Woodward, C., Lo, C., Lawton, M., Sulzer, P., Hanff, A.M., Kruger, R., Liepelt-Scarfone, I., Hu, M.T., Ncer, P.D., Exploration of whether socioeconomic factors affect the results of priority setting partnerships: updating the top 10 research priorities for the management of Parkinson's in an international setting. BMJ Open, 12(6), 2022, e049530.
Bouca-Machado, R., Duarte, G.S., Patriarca, M., Castro Caldas, A., Alarcao, J., Fernandes, R.M., Mestre, T.A., Matias, R., Ferreira, J.J., Measurement instruments to assess functional mobility in Parkinson's disease: a systematic review. Mov. Disord. Clin. Pract. 7:2 (2020), 129–139.
Johnston, B.C., Patrick, D.L., Devji, T., Maxwell, L.J., C.O.B III, Beaton, D.E., Boers, M., Briel, M., Busse, J.W., Carrasco-Labra, A., Christensen, R., Costa, B.R.d., Dib, R.E., Lyddiatt, A., Ostelo, R.W., Shea, B., Singh, J., Terwee, C.B., Williamson, P.R., Gagnier, J.J., Tugwell, P., Guyatt, G.H., Chapter 18: patient-reported outcomes. Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., Welch, V.A., (eds.) Cochrane Handbook for Systematic Reviews of Interventions Version 6.3, 2022, Cochrane.
Peto, V., Jenkinson, C., Fitzpatrick, R., Greenhall, R., The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease. Qual. Life Res. 4:3 (1995), 241–248.
Vervoort, G., Bengevoord, A., Strouwen, C., Bekkers, E.M., Heremans, E., Vandenberghe, W., Nieuwboer, A., Progression of postural control and gait deficits in Parkinson's disease and freezing of gait: a longitudinal study. Parkinsonism Relat. Disorders 28 (2016), 73–79.
Jaywant, A., Ellis, T.D., Roy, S., Lin, C.C., Neargarder, S., Cronin-Golomb, A., Randomized controlled trial of a home-based action observation intervention to improve walking in Parkinson disease. Arch. Phys. Med. Rehabil. 97:5 (2016), 665–673.
Med Collaborative Group, P.D., Gray, R., Ives, N., Rick, C., Patel, S., Gray, A., Jenkinson, C., McIntosh, E., Wheatley, K., Williams, A., Clarke, C.E., Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet 384:9949 (2014), 1196–1205.
Stocchi, F., Abbruzzese, G., Ceravolo, R., Cortelli, P., D'Amelio, M., De Pandis, M.F., Fabbrini, G., Pacchetti, C., Pezzoli, G., Tessitore, A., Canesi, M., Iannacone, C., Zappia, M., Group, F.S., Prevalence of fatigue in Parkinson disease and its clinical correlates. Neurology 83:3 (2014), 215–220.
de Vet, H.C.W., Terwee, C.B., Mokkink, L.B., Knol, D.L., Measurement in Medicine. A Practical Guide. 2011, Cambridge University Press, Cambridge.
Hipp, G., Vaillant, M., Diederich, N.J., Roomp, K., Satagopam, V.P., Banda, P., Sandt, E., Mommaerts, K., Schmitz, S.K., Longhino, L., Schweicher, A., Hanff, A.M., Nicolai, B., Kolber, P., Reiter, D., Pavelka, L., Binck, S., Pauly, C., Geffers, L., Betsou, F., Gantenbein, M., Klucken, J., Gasser, T., Hu, M.T., Balling, R., Kruger, R., The Luxembourg Parkinson's study: a comprehensive approach for stratification and early diagnosis. Front. Aging Neurosci., 10, 2018, 326.
Podsiadlo, D., Richardson, S., The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J. Am. Geriatr. Soc. 39:2 (1991), 142–148.
Stebbins, G.T., Goetz, C.G., Burn, D.J., Jankovic, J., Khoo, T.K., Tilley, B.C., How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. Mov. Disord. 28:5 (2013), 668–670.
Goetz, C.G., Tilley, B.C., Shaftman, S.R., Stebbins, G.T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M.B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A.E., Lees, A., Leurgans, S., LeWitt, P.A., Nyenhuis, D., Olanow, C.W., Rascol, O., Schrag, A., Teresi, J.A., van Hilten, J.J., LaPelle, N., Movement Disorder Society, U.R.T.F., Movement disorder society-sponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. 23:15 (2008), 2129–2170.
R Core Team, R: A Language and Environment for Statistical Computing. 2021 https://www.R-project.org/.
Wickham, H., Elegant Graphics for Data Analysis. 2016, Springer-Verlag, New York.
Rosseel, Y., Lavaan: an R package for structural equation modeling. J. Stat. Software 48:2 (2012), 1–36.
The Jamovi Project, 2021, jamovi.
Fleming, A., Cook, K.F., Nelson, N.D., Lai, E.C., Proxy reports in Parkinson's disease: caregiver and patient self-reports of quality of life and physical activity. Mov. Disord. 20:11 (2005), 1462–1468.
Prinsen, C.A.C., Mokkink, L.B., Bouter, L.M., Alonso, J., Patrick, D.L., de Vet, H.C.W., Terwee, C.B., COSMIN guideline for systematic reviews of patient-reported outcome measures. Qual. Life Res. 27:5 (2018), 1147–1157.
Chang, W., Cheng, J., Allaire, J., Sievert, C., Schloerke, B., Xie, Y., Allen, J., McPherson, J., Dipert, A., Borges, B., Shiny: Web Application. Framework for R. 2022 https://CRAN.R-project.org/package=shiny.
